Role of ATP-binding cassette transporters in cancer initiation and progression.
ATP-Binding Cassette Transporters
/ chemistry
Animals
Biomarkers
Cell Transformation, Neoplastic
/ genetics
Disease Progression
Disease Susceptibility
Drug Resistance, Neoplasm
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Neoplasms
/ drug therapy
Neoplastic Stem Cells
/ metabolism
Signal Transduction
Structure-Activity Relationship
ABC transporter druggability
ABC transporters
Cancer initiation
Cancer progression
Cancer stem cells
Epithelial mesenchymal transition
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
03
07
2019
revised:
07
08
2019
accepted:
07
08
2019
pubmed:
15
8
2019
medline:
18
12
2020
entrez:
15
8
2019
Statut:
ppublish
Résumé
ATP Binding Cassette (ABC) transporters, widely studied in cancer for their role in drug resistance, have been more recently also considered for their contribution to cancer cell biology. To date, many data provide evidences for their potential role in all the phases of cancer development from cancer susceptibility, tumor initiation, tumor progression and metastasis. Although many evidences are based on correlative analyses, data describing a direct or indirect role of ABC transporters in cancer biology are increasing. Overall, current available information suggests a relevant molecular effector role of some ABC transporters in cancer invasion and metastasis as reported in experimental tumor models. From a therapeutic point of view, due to the physiological relevant roles that ABC transporters play in the organism, the capability to selectively inhibit the function or the expression of ABC transporters in cancer stem cells or other tumor cells, represents the main challenge for researcher scientists. A detailed and updated description of the current knowledge on the role of ABC transporters in cancer biology is provided.
Identifiants
pubmed: 31412294
pii: S1044-579X(19)30228-7
doi: 10.1016/j.semcancer.2019.08.006
pii:
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-95Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.