Risk of Zika microcephaly correlates with features of maternal antibodies.

Animals Antibodies, Viral / immunology Brain / embryology Female Fetus / embryology Humans K562 Cells Macaca mulatta Macaca nemestrina Maternal-Fetal Exchange / immunology Microcephaly / immunology Pregnancy Pregnancy Complications, Infectious / immunology Zika Virus / immunology Zika Virus Infection / immunology

Journal

The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R

Informations de publication

Date de publication:
07 10 2019
Historique:
received: 12 06 2019
revised: 15 07 2019
accepted: 16 07 2019
pubmed: 16 8 2019
medline: 11 6 2020
entrez: 16 8 2019
Statut: ppublish

Résumé

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

Identifiants

DOI: 10.1084/jem.20191061 PMID: 31413072 PMC: PMC6781003
pubmed: 31413072
pii: jem.20191061
doi: 10.1084/jem.20191061
pmc: PMC6781003
doi:

Substances chimiques

Antibodies, Viral 0

Banques de données

GENBANK
['KU501215', 'KU321639.1', 'KU955593', 'KX811222', 'KJ776791']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2302-2315

Subventions

Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW010540
Pays : United States
Organisme : NIH HHS
ID : P51 OD010425
Pays : United States
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138938
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133976
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100989
Pays : United States
Organisme : FIC NIH HHS
ID : R01 TW009504
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104002
Pays : United States
Organisme : NIH HHS
ID : P51 OD011106
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083091
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI083019
Pays : United States
Organisme : FIC NIH HHS
ID : R25 TW009338
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129479
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145296
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121207
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111825
Pays : United States

Informations de copyright

© 2019 Robbiani et al.

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Auteurs

Davide F Robbiani (DF)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY drobbiani@rockefeller.edu.
ORCID: 0000-0001-7379-3484

Priscilla C Olsen (PC)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Federico Costa (F)

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

Qiao Wang (Q)

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
ORCID: 0000-0001-6416-1733

Thiago Y Oliveira (TY)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.

Nivison Nery (N)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.

Adeolu Aromolaran (A)

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.

Mateus S do Rosário (MS)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.

Gielson A Sacramento (GA)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.

Jaqueline S Cruz (JS)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.

Ricardo Khouri (R)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.

Elsio A Wunder (EA)

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
ORCID: 0000-0002-5239-8511

Adriana Mattos (A)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.

Bruno de Paula Freitas (B)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Universidade Federal de São Paulo, São Paulo, Brazil.

Manoel Sarno (M)

Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

Gracinda Archanjo (G)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.

Dina Daltro (D)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.

Gustavo B S Carvalho (GBS)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.

Kleber Pimentel (K)

Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.

Isadora C de Siqueira (IC)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
ORCID: 0000-0002-2520-4099

João R M de Almeida (JRM)

Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
ORCID: 0000-0002-2747-7218

Daniele F Henriques (DF)

Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.

Juliana A Lima (JA)

Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.

Pedro F C Vasconcelos (PFC)

Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.

Dennis Schaefer-Babajew (D)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.

Stephanie A Azzopardi (SA)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.

Leonia Bozzacco (L)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.

Anna Gazumyan (A)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.

Rubens Belfort (R)

Universidade Federal de São Paulo, São Paulo, Brazil.
ORCID: 0000-0002-8422-3898

Ana P Alcântara (AP)

Hospital Santo Amaro, Salvador, Bahia, Brazil.

Gustavo Carvalho (G)

Hospital Santo Amaro, Salvador, Bahia, Brazil.

Licia Moreira (L)

Hospital Santo Amaro, Salvador, Bahia, Brazil.
ORCID: 0000-0001-5009-8577

Katiaci Araujo (K)

Hospital Aliança, Salvador, Bahia, Brazil.

Mitermayer G Reis (MG)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

Rebekah I Keesler (RI)

California National Primate Research Center, University of California, Davis, Davis, CA.

Lark L Coffey (LL)

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.

Jennifer Tisoncik-Go (J)

Washington National Primate Research Center, Seattle, WA.
Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.
Department of Immunology, University of Washington, Seattle, WA.

Michael Gale (M)

Washington National Primate Research Center, Seattle, WA.
Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.
Department of Immunology, University of Washington, Seattle, WA.
Department of Global Health, University of Washington, Seattle, WA.
ORCID: 0000-0002-6332-7436

Lakshmi Rajagopal (L)

Department of Global Health, University of Washington, Seattle, WA.
Department of Pediatrics, University of Washington, Seattle, WA.
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA.

Kristina M Adams Waldorf (KM)

Washington National Primate Research Center, Seattle, WA.
Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.
Department of Global Health, University of Washington, Seattle, WA.
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA.

Dawn M Dudley (DM)

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.
ORCID: 0000-0003-0934-2042

Heather A Simmons (HA)

Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.

Andres Mejia (A)

Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.
ORCID: 0000-0001-6088-3595

David H O'Connor (DH)

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.

Rosemary J Steinbach (RJ)

Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.

Nicole Haese (N)

Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.
ORCID: 0000-0003-4871-2763

Jessica Smith (J)

Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.

Anne Lewis (A)

Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR.
ORCID: 0000-0003-4059-7318

Lois Colgin (L)

Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.

Victoria Roberts (V)

Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.

Antonio Frias (A)

Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR.

Meredith Kelleher (M)

Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.
ORCID: 0000-0002-5313-004X

Alec Hirsch (A)

Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.

Daniel N Streblow (DN)

Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.

Charles M Rice (CM)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.

Margaret R MacDonald (MR)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
ORCID: 0000-0001-5177-2068

Antonio R P de Almeida (ARP)

Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

Koen K A Van Rompay (KKA)

California National Primate Research Center, University of California, Davis, Davis, CA.
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.
ORCID: 0000-0002-7375-1337

Albert I Ko (AI)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
ORCID: 0000-0001-9023-2339

Michel C Nussenzweig (MC)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY nussen@rockefeller.edu.
Howard Hughes Medical Institute, The Rockefeller University, New York, NY.
ORCID: 0000-0003-0592-8564

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Structures de l'embryon › Foetus › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Cellules › Cellules érythroïdes › Cellules K562 › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca nemestrina › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Échange foetomaternel › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Malformations corticales › Malformations corticales du groupe I › Microcéphalie › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications infectieuses de la grossesse › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus Zika › Risk of Zika microcephaly correlates with...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Flaviviridae › Infections à flavivirus › Infection par le virus Zika › Risk of Zika microcephaly correlates with...