Vaccination of Macaques with DNA Followed by Adenoviral Vectors Encoding Simian Immunodeficiency Virus (SIV) Gag Alone Delays Infection by Repeated Mucosal Challenge with SIV.
Adenoviridae
/ genetics
Animals
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Defective Viruses
/ genetics
Gene Products, gag
/ genetics
Genetic Vectors
/ genetics
Macaca fascicularis
Male
SAIDS Vaccines
/ administration & dosage
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ genetics
Vaccination
Vaccines, DNA
/ administration & dosage
Viral Load
DNA vaccine
SIV
adenovirus vector
gag
simian immunodeficiency virus
vaccine
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
10
04
2019
accepted:
06
08
2019
pubmed:
16
8
2019
medline:
17
6
2020
entrez:
16
8
2019
Statut:
epublish
Résumé
Vaccines aimed at inducing T cell responses to protect against human immunodeficiency virus (HIV) infection have been under development for more than 15 years. Replication-defective adenovirus (rAd) vaccine vectors are at the forefront of this work and have been tested extensively in the simian immunodeficiency virus (SIV) challenge macaque model. Vaccination with rAd vectors coding for SIV Gag or other nonenvelope proteins induces T cell responses that control virus load but disappointingly is unsuccessful so far in preventing infection, and attention has turned to inducing antibodies to the envelope. However, here we report that Mauritian cynomolgus macaques (MCM),
Identifiants
pubmed: 31413132
pii: JVI.00606-19
doi: 10.1128/JVI.00606-19
pmc: PMC6803269
pii:
doi:
Substances chimiques
Gene Products, gag
0
SAIDS Vaccines
0
Vaccines, DNA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Almond et al.
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