Correlation between Osteoprotegerin Levels and Antiphospholipid Syndrome Parameters.
antiphospholipid syndrome
cardiovascular risk
osteoprotegerin
stroke
systemic lupus erythematosus
thrombosis
Journal
Laboratory medicine
ISSN: 1943-7730
Titre abrégé: Lab Med
Pays: England
ID NLM: 0250641
Informations de publication
Date de publication:
10 Mar 2020
10 Mar 2020
Historique:
pubmed:
16
8
2019
medline:
24
4
2020
entrez:
16
8
2019
Statut:
ppublish
Résumé
To identify the osteoprotegerin (OPG) correlates with antiphospholipid syndrome (APS) parameters. Our cohort included 40 patients with primary APS disease associated with systemic lupus erythematosus (SLE) (mean age, 43.7 years; 87% female). Data on cardiovascular risk factors and specific clinical events in APS were collected. Then we tested OPG and 10 criteria and noncriteria antiphospholipid antibodies (aPLs) on preserved specimens in all cases. A total of 26 patients (65%) had high serum OPG levels. Patients with high OPG were mostly overweight. In patients with SLE, the OPG levels were associated with anti-double-stranded DNA (anti-dsDNA) and anti-Sm titers. However, we did not find significant correlations of the OPG with any of the 10 aPLs tested. Also, we found no relationship regarding venous APS events. In APS, high OPG levels are not linked to serum aPL expression.
Identifiants
pubmed: 31414130
pii: 5550246
doi: 10.1093/labmed/lmz051
doi:
Substances chimiques
Autoantibodies
0
Osteoprotegerin
0
TNFRSF11B protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-198Informations de copyright
© American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.