Topical Esomeprazole Mitigates Radiation-Induced Dermal Inflammation and Fibrosis.
Active Transport, Cell Nucleus
Administration, Topical
Animals
Anti-Inflammatory Agents
/ administration & dosage
Disease Models, Animal
Esomeprazole
/ administration & dosage
Fibrosis
/ drug therapy
Gene Expression Profiling
Heme Oxygenase-1
/ metabolism
Humans
Inflammation
/ drug therapy
Male
Membrane Proteins
/ metabolism
Mice
Mice, Inbred C57BL
Models, Anatomic
NF-E2-Related Factor 2
/ metabolism
Radiodermatitis
/ drug therapy
Radiotherapy
/ adverse effects
Skin
/ drug effects
Wound Healing
/ drug effects
Journal
Radiation research
ISSN: 1938-5404
Titre abrégé: Radiat Res
Pays: United States
ID NLM: 0401245
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
16
8
2019
medline:
6
2
2020
entrez:
16
8
2019
Statut:
ppublish
Résumé
Radiation therapy is a mainstream strategy in the treatment of several cancer types that are surgically unresectable. Unfortunately, cancer patients often suffer from unintended consequences of radiotherapy, including the development of skin inflammation (dermatitis), which may progress to fibrosis. These morbid complications often require interruption of radiotherapy and threaten the relapse of underlying cancer. Current treatment options for radiation dermatitis are suboptimal and compel the need to develop safer, more effective therapies. In this study, we assessed the biophysical properties of topically-formulated esomeprazole (here referred to as dermaprazole) and performed proof-of-concept studies to evaluate its efficacy
Identifiants
pubmed: 31415221
pii: 10.1667/RR15398.1
doi: 10.1667/RR15398.1
pmc: PMC6876297
mid: NIHMS1059282
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Membrane Proteins
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Nfe2l2 protein, mouse
0
HMOX1 protein, human
EC 1.14.14.18
Heme Oxygenase-1
EC 1.14.14.18
Hmox1 protein, mouse
EC 1.14.14.18
Esomeprazole
N3PA6559FT
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
473-482Subventions
Organisme : NICHD NIH HHS
ID : P01 HD087157
Pays : United States
Organisme : NIDCR NIH HHS
ID : F31 DE026682
Pays : United States
Organisme : BLRD VA
ID : IK2 BX004183
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137703
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL118683
Pays : United States
Organisme : FDA HHS
ID : R01 FD005109
Pays : United States
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