miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.
3' Untranslated Regions
/ genetics
Adenocarcinoma
/ genetics
Animals
Cell Line, Tumor
Colorectal Neoplasms
/ genetics
Gene Expression Regulation, Neoplastic
Genes, Reporter
Heterografts
Humans
Mice
Mice, Inbred NOD
Mice, SCID
MicroRNAs
/ biosynthesis
Neoplasm Proteins
/ biosynthesis
Neoplasm Transplantation
Neoplastic Stem Cells
/ cytology
Organoids
Protein Isoforms
/ biosynthesis
RNA, Neoplasm
/ biosynthesis
RNA-Binding Proteins
/ biosynthesis
Recombinant Proteins
/ metabolism
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
17
11
2018
revised:
29
06
2019
accepted:
07
08
2019
pubmed:
17
8
2019
medline:
2
6
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
miRNAs are key players in the integrated regulation of cellular processes and shape many of the functional properties that define the "cancer stem cell" (CSC) phenotype. Little is known, however, about miRNAs that regulate such properties in human colorectal carcinoma. In this study, we compared the expression levels of 754 miRNAs between paired samples of EpCAM
Identifiants
pubmed: 31416845
pii: 0008-5472.CAN-18-3544
doi: 10.1158/0008-5472.CAN-18-3544
pmc: PMC6801097
mid: NIHMS1538524
doi:
Substances chimiques
3' Untranslated Regions
0
MIRN221 microRNA, human
0
MicroRNAs
0
Neoplasm Proteins
0
Protein Isoforms
0
RNA, Neoplasm
0
RNA-Binding Proteins
0
RNA-binding protein QKI-5, human
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5151-5158Subventions
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIH HHS
ID : S10 OD020056
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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