Muscarinic Inhibition of Hypoglossal Motoneurons: Possible Implications for Upper Airway Muscle Hypotonia during REM Sleep.
Animals
Carbachol
/ pharmacology
Channelrhodopsins
Female
Glutamates
/ physiology
Hypoglossal Nerve
/ drug effects
Male
Mice
Motor Neurons
Muscarinic Agonists
/ pharmacology
Muscle Hypotonia
/ physiopathology
Neurons, Afferent
/ drug effects
Optogenetics
Parasympathetic Nervous System
/ drug effects
Patch-Clamp Techniques
Respiratory Muscles
/ physiopathology
Sleep, REM
Synapses
/ drug effects
brain slices
cholinergic transmission
electrophysiology
mice
muscarinic receptors
optogenetics
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
02 10 2019
02 10 2019
Historique:
received:
27
02
2019
revised:
08
07
2019
accepted:
13
08
2019
pubmed:
20
8
2019
medline:
3
7
2020
entrez:
18
8
2019
Statut:
ppublish
Résumé
Proper function of pharyngeal dilator muscles, including the genioglossus muscle of the tongue, is required to maintain upper airway patency. During sleep, the activity of these muscles is suppressed, and as a result individuals with obstructive sleep apnea experience repeated episodes of upper airway closure when they are asleep, in particular during rapid-eye-movement (REM) sleep. Blocking cholinergic transmission in the hypoglossal motor nucleus (MoXII) restores REM sleep genioglossus activity, highlighting the importance of cholinergic transmission in the inhibition of hypoglossal motor neurons (HMNs) during REM sleep. Glutamatergic afferent input from neurons in the parahypoglossal (PH) region to the HMNs is critical for MoXII respiratory motor output. We hypothesized that state-dependent cholinergic regulation may be mediated by this pathway. Here we studied the effects of cholinergic transmission in HMNs in adult male and female mice using patch-clamp recordings in brain slices. Using channelrhodopsin-2-assisted circuit mapping, we first demonstrated that PH glutamatergic neurons directly and robustly activate HMNs (PH
Identifiants
pubmed: 31420456
pii: JNEUROSCI.0461-19.2019
doi: 10.1523/JNEUROSCI.0461-19.2019
pmc: PMC6774407
doi:
Substances chimiques
Channelrhodopsins
0
Glutamates
0
Muscarinic Agonists
0
Carbachol
8Y164V895Y
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
7910-7919Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL095491
Pays : United States
Informations de copyright
Copyright © 2019 the authors.
Références
Am J Respir Crit Care Med. 2000 May;161(5):1746-9
pubmed: 10806181
J Comp Neurol. 2010 May 15;518(10):1862-78
pubmed: 20235095
Clin Anat. 2010 Oct;23(7):777-91
pubmed: 20607833
Nature. 2009 Feb 26;457(7233):1142-5
pubmed: 19151697
J Neurosci. 1998 May 1;18(9):3138-46
pubmed: 9547222
Elife. 2014 Apr 30;3:e02511
pubmed: 24843003
Eur J Neurosci. 1999 Aug;11(8):2737-48
pubmed: 10457170
J Neurosci. 2014 Apr 23;34(17):6023-9
pubmed: 24760861
Front Neurol. 2018 Sep 10;9:752
pubmed: 30250449
J Physiol. 2005 Jun 15;565(Pt 3):965-80
pubmed: 15817635
Elife. 2015 Dec 19;4:
pubmed: 26687006
Brain Res Brain Res Rev. 1997 Dec;25(3):291-311
pubmed: 9495560
J Appl Physiol (1985). 2014 Feb 1;116(3):325-36
pubmed: 23970535
J Chem Neuroanat. 2010 Nov;40(3):223-31
pubmed: 20566330
Neuroscience. 2002;115(3):861-70
pubmed: 12435424
J Physiol. 1991 May;436:15-29
pubmed: 2061830
Int J Dev Neurosci. 2015 Dec;47(Pt B):183-91
pubmed: 26440997
Respir Physiol Neurobiol. 2011 Oct 15;179(1):43-7
pubmed: 21741499
Am J Respir Crit Care Med. 2019 May 15;199(10):1267-1276
pubmed: 30395486
Respir Physiol. 2001 Sep;127(2-3):217-26
pubmed: 11504591
Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1880-7
pubmed: 8665050
Neuroscience. 2017 Jan 6;340:62-75
pubmed: 27984184
Compr Physiol. 2016 Sep 15;6(4):1801-1850
pubmed: 27783860
Sleep. 1978 Sep;1(1):49-68
pubmed: 227023
Neurosci Lett. 2007 Feb 14;413(2):121-5
pubmed: 17174027
J Comp Neurol. 2005 Jul 18;488(1):28-47
pubmed: 15912497
Clin Exp Pharmacol Physiol. 2000 Jan-Feb;27(1-2):132-7
pubmed: 10696542
Am J Respir Crit Care Med. 2005 Dec 1;172(11):1363-70
pubmed: 16100008
Neuron. 2011 Jul 14;71(1):142-54
pubmed: 21745644
J Appl Physiol (1985). 2008 Nov;105(5):1576-84
pubmed: 18772326
J Appl Physiol Respir Environ Exerc Physiol. 1982 Feb;52(2):438-44
pubmed: 7037716
Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2553-64
pubmed: 19651656
J Neurophysiol. 1996 Dec;76(6):3758-70
pubmed: 8985874
J Comp Neurol. 1995 Feb 27;353(1):89-108
pubmed: 7714251
Brain Res. 1979 Jul 20;170(3):533-7
pubmed: 88998
eNeuro. 2018 May 28;5(3):
pubmed: 29845107
Prog Brain Res. 2014;209:255-74
pubmed: 24746052
Brain Res. 2011 Aug 2;1404:10-20
pubmed: 21724177
Respir Physiol. 1998 Sep;113(3):191-200
pubmed: 9840328
Front Neurol. 2015 Dec 01;6:254
pubmed: 26648908
J Physiol. 1999 Nov 1;520 Pt 3:897-908
pubmed: 10545152
J Physiol. 2001 Nov 15;537(Pt 1):251-65
pubmed: 11711578
Exp Brain Res. 1985;59(1):16-29
pubmed: 4018194
Curr Biol. 2016 Aug 22;26(16):2137-43
pubmed: 27426511
J Physiol. 1994 Feb 1;474(3):525-37
pubmed: 8014911
Eur J Neurosci. 2005 Dec;22(11):2723-34
pubmed: 16324106
Nature. 2014 Mar 13;507(7491):238-42
pubmed: 24487620
J Physiol. 2002 Feb 1;538(Pt 3):957-73
pubmed: 11826179
Am J Physiol Cell Physiol. 2013 Nov 15;305(10):C1080-90
pubmed: 23986203
Sleep. 2016 Mar 01;39(3):511-21
pubmed: 26612386
Am J Respir Crit Care Med. 2013 Feb 1;187(3):311-9
pubmed: 23220910
J Physiol. 1994 Apr 1;476(1):141-51
pubmed: 8046629
J Appl Physiol (1985). 2012 Oct;113(7):1024-39
pubmed: 22858620
J Physiol. 1999 Sep 1;519 Pt 2:601-13
pubmed: 10457075
Exp Neurol. 1976 Apr;51(1):160-70
pubmed: 177304
Lancet. 2002 Jul 20;360(9328):237-45
pubmed: 12133673
J Physiol. 2007 Mar 1;579(Pt 2):515-26
pubmed: 17185342
J Comp Neurol. 1995 Jul 3;357(3):376-94
pubmed: 7673474
Front Cell Neurosci. 2017 Dec 05;11:383
pubmed: 29259542
J Neurosci. 2009 Jul 15;29(28):8991-5
pubmed: 19605636
J Neurophysiol. 2000 May;83(5):2987-95
pubmed: 10805694
J Neurophysiol. 1994 Nov;72(5):2538-41
pubmed: 7884479
J Comp Neurol. 2018 Jun 1;526(8):1389-1402
pubmed: 29473167
J Neurosci. 2018 Feb 7;38(6):1588-1599
pubmed: 29311142
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1058-62
pubmed: 10988130
Physiol Genomics. 2006 Nov 27;27(3):391-7
pubmed: 16940431
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4471-6
pubmed: 21368172
Pathol Biol (Paris). 2014 Oct;62(5):233-40
pubmed: 25070768
J Neurosci. 2014 Mar 26;34(13):4708-27
pubmed: 24672016