Atropisomeric bi(9,10-dihydro)phenanthrene and phenanthrene/bibenzyl dimers with cytotoxic activity from the pseudobulbs of Pleione bulbocodioides.
Bi(9,10-dihydro)phenanthrene
Cytotoxic activity
NMR spectroscopic data
Phenanthrene/bibenzyl atropisomers
Pleione bulbocodioides
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
18
07
2019
revised:
13
08
2019
accepted:
13
08
2019
pubmed:
20
8
2019
medline:
4
12
2019
entrez:
18
8
2019
Statut:
ppublish
Résumé
Bulbocodioidins E-H (1-4), four pairs of undescribed racemic bi(9,10-dihydro)phenanthrene and phenanthrene/bibenzyl atropisomers, along with four known compounds (5-8) were isolated from the ethanol extract of the pseudobulbs of Pleione bulbocodioides. Their structures were established by HRESIMS and comprehensive NMR spectroscopic data analysis. Their absolute configurations were elucidated by comparison of their experimental and calculated ECD (electronic circular dichroism) curves. Furthermore, compound 4a displayed cytotoxic activity against colon cancer (HCT-116), liver cancer (HepG2), and breast cancer (MCF-7) cell lines with IC
Identifiants
pubmed: 31421147
pii: S0367-326X(19)31480-7
doi: 10.1016/j.fitote.2019.104313
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Bibenzyls
0
Phenanthrenes
0
Phytochemicals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104313Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.