Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring.
Melatonin
Metabolism
Offspring
Pregnancy
Shift work
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
07
10
2018
revised:
01
08
2019
accepted:
05
08
2019
pubmed:
20
8
2019
medline:
2
5
2020
entrez:
18
8
2019
Statut:
ppublish
Résumé
Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring. It is therefore postulated that female night workers when pregnant may expose the offspring to unwanted health threats. This may be explained by the fact that melatonin is essential for regulating energy metabolism and can influence reproductive activity. Moreover, the circadian misalignment caused by shift work affects fertility and the fetus, increasing the risk of miscarriage, premature birth and low birth weight, phenomena observed in night workers. Thus, we hypothesize that light-induced melatonin suppression as a result of night work may alter intrauterine metabolic programming in pregnant women, potentially leading to metabolic disorders in their offspring.
Identifiants
pubmed: 31421432
pii: S0306-9877(18)31050-8
doi: 10.1016/j.mehy.2019.109353
pii:
doi:
Substances chimiques
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109353Subventions
Organisme : Medical Research Council
ID : MR/N006321/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.