Improving CNS Delivery to Brain Metastases by Blood-Tumor Barrier Disruption.
blood–brain barrier
blood–tumor barrier
disruption
permeability
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
24
04
2019
revised:
07
06
2019
accepted:
21
06
2019
entrez:
19
8
2019
pubmed:
20
8
2019
medline:
1
8
2020
Statut:
ppublish
Résumé
Brain metastases encompass nearly 80% of all intracranial tumors. A late stage diagnosis confers a poor prognosis, with patients typically surviving less than 2 years. Poor survival can be equated to limited effective treatment modalities. One reason for the failure rates is the presence of the blood-brain barrier (BBB) and blood-tumor barrier (BTB) that limit the access of potentially effective chemotherapeutics to metastatic lesions. Strategies to overcome these barriers include new small molecule entities capable of crossing into the brain parenchyma, novel formulations of existing chemotherapies, and disruptive techniques. Here, we review BBB physiology and BTB pathophysiology. Additionally, we review the limitations of routinely practiced therapies and three current methods being explored for BBB/BTB disruption for improved delivery of chemotherapy to brain tumors.
Identifiants
pubmed: 31421906
pii: S2405-8033(19)30122-0
doi: 10.1016/j.trecan.2019.06.003
pmc: PMC6703178
mid: NIHMS1532926
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
495-505Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121322
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA166067
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052375
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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