Inter-organ communication: a gatekeeper for metabolic health.
energy homeostasis
inter-organ communication
metabolism
obesity
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
11
02
2019
revised:
21
05
2019
accepted:
24
05
2019
pubmed:
20
8
2019
medline:
2
6
2020
entrez:
20
8
2019
Statut:
ppublish
Résumé
Multidirectional interactions between metabolic organs in the periphery and the central nervous system have evolved concomitantly with multicellular organisms to maintain whole-body energy homeostasis and ensure the organism's adaptation to external cues. These interactions are altered in pathological conditions such as obesity and type 2 diabetes. Bioactive peptides and proteins, such as hormones and cytokines, produced by both peripheral organs and the central nervous system, are key messengers in this inter-organ communication. Despite the early discovery of the first hormones more than 100 years ago, recent studies taking advantage of novel technologies have shed light on the multiple ways used by cells in the body to communicate and maintain energy balance. This review briefly summarizes well-established concepts and focuses on recent advances describing how specific proteins and peptides mediate the crosstalk between gut, brain, and other peripheral metabolic organs in order to maintain energy homeostasis. Additionally, this review outlines how the improved knowledge about these inter-organ networks is helping us to redefine therapeutic strategies in an effort to promote healthy living and fight metabolic disorders and other diseases.
Identifiants
pubmed: 31423716
doi: 10.15252/embr.201947903
pmc: PMC6726901
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e47903Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Cell Metab. 2017 Aug 1;26(2):437-446.e5
pubmed: 28768181
Nature. 2018 Aug;560(7716):102-106
pubmed: 30022159
Mol Metab. 2017 May 04;6(9):1052-1065
pubmed: 28951828
Nat Rev Endocrinol. 2018 Dec;15(1):1
pubmed: 30487533
Metabolism. 2018 Apr;81:63-70
pubmed: 29155135
Nature. 2018 Aug;560(7719):499-503
pubmed: 30051890
J Anat. 2009 Jan;214(1):171-8
pubmed: 19018882
PLoS One. 2013 May 30;8(5):e64859
pubmed: 23738005
Nature. 1997 May 1;387(6628):83-90
pubmed: 9139826
Diabetologia. 2011 Jun;54(6):1491-501
pubmed: 21347623
Nat Rev Gastroenterol Hepatol. 2019 Jan;16(1):35-56
pubmed: 30262901
Nature. 2017 Feb 23;542(7642):450-455
pubmed: 28199304
Cell Metab. 2015 Mar 3;21(3):403-16
pubmed: 25738456
Cell Rep. 2016 Nov 8;17(7):1795-1806
pubmed: 27829151
Mol Metab. 2016 Jun 30;5(8):626-634
pubmed: 27656400
Trends Pharmacol Sci. 2015 Jul;36(7):461-70
pubmed: 26022934
Physiol Behav. 1982 Dec;29(6):1137-40
pubmed: 7163393
Nature. 2012 Jan 11;481(7382):463-8
pubmed: 22237023
Cell Metab. 2011 Apr 6;13(4):401-412
pubmed: 21459325
Cell Rep. 2019 Jan 8;26(2):346-355.e3
pubmed: 30625317
Cell. 2015 Sep 24;163(1):84-94
pubmed: 26406372
Cell Metab. 2007 Jul;6(1):3-4
pubmed: 17618851
Eur J Neurosci. 2005 Sep;22(5):1169-75
pubmed: 16176359
Cell Metab. 2018 Jan 9;27(1):226-236.e3
pubmed: 29320703
Nat Rev Endocrinol. 2017 Feb;13(2):72-74
pubmed: 28051119
FASEB J. 2013 May;27(5):1981-9
pubmed: 23362117
Nature. 1999 Dec 9;402(6762):656-60
pubmed: 10604470
Cell. 2015 Jan 15;160(1-2):88-104
pubmed: 25594176
Cell Metab. 2014 Mar 4;19(3):527-38
pubmed: 24606905
Cell Metab. 2013 May 7;17(5):790-7
pubmed: 23663742
Nature. 2013 Nov 28;503(7477):493-9
pubmed: 24172895
Diabetes. 2015 Jul;64(7):2352-60
pubmed: 26050667
Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945
pubmed: 29967167
Cell. 2014 Jun 5;157(6):1279-1291
pubmed: 24906147
Nature. 2006 Jan 26;439(7075):484-9
pubmed: 16400329
Cell Metab. 2017 Oct 3;26(4):686-692.e3
pubmed: 28918935
J Clin Invest. 2012 Sep;122(9):3035-43
pubmed: 22945636
J Physiol. 1902 Sep 12;28(5):325-53
pubmed: 16992627
Neuropsychopharmacology. 2011 Jan;36(2):459-71
pubmed: 20927047
Nat Cell Biol. 2017 Aug;19(8):974-987
pubmed: 28737771
PLoS One. 2012;7(12):e51898
pubmed: 23251649
Cell Rep. 2019 Mar 5;26(10):2720-2737.e5
pubmed: 30840893
J Biol Chem. 2011 Apr 15;286(15):12983-90
pubmed: 21317437
Endocrinology. 2004 Nov;145(11):4880-9
pubmed: 15271881
Diabetes Res Clin Pract. 2018 Jan;135:7-10
pubmed: 29097285
Nat Biotechnol. 2010 Dec;28(12):1248-50
pubmed: 21139605
Cell Metab. 2016 Aug 9;24(2):192-3
pubmed: 27508865
Diabetologia. 2007 Feb;50(2):370-9
pubmed: 17136393
Front Physiol. 2018 Sep 24;9:1307
pubmed: 30319436
Cell Metab. 2017 Nov 7;26(5):801
pubmed: 29117546
Cell Metab. 2007 Jun;5(6):415-25
pubmed: 17550777
J Clin Invest. 2000 Aug;106(4):473-81
pubmed: 10953022
Nat Med. 2002 Dec;8(12):1376-82
pubmed: 12426561
J Lipid Res. 2014 Feb;55(2):180-9
pubmed: 24285857
Front Physiol. 2014 Dec 11;5:479
pubmed: 25566082
Cell Metab. 2018 Feb 6;27(2):461-469.e6
pubmed: 29233536
J Clin Invest. 2006 Jul;116(7):1983-93
pubmed: 16767221
Mol Cell Endocrinol. 2010 Apr 29;318(1-2):34-43
pubmed: 19747957
Int J Obes (Lond). 2010 Oct;34 Suppl 1:S36-42
pubmed: 20935665
Cell Metab. 2014 Feb 4;19(2):302-9
pubmed: 24506871
Cell Metab. 2015 May 5;21(5):731-8
pubmed: 25955208
Lancet Diabetes Endocrinol. 2013 Nov;1(3):250-8
pubmed: 24622373
Cell. 2018 Apr 19;173(3):554-567
pubmed: 29677509
Diabetes Metab J. 2013 Feb;37(1):22-9
pubmed: 23441053
Nature. 2002 Jan 17;415(6869):339-43
pubmed: 11797013
Mol Endocrinol. 2011 Sep;25(9):1600-11
pubmed: 21719535
Diabetes Obes Metab. 2014 Jan;16(1):9-21
pubmed: 23617798
Mol Metab. 2016 Jun 29;5(8):589-601
pubmed: 27656397
Cell Metab. 2005 Oct;2(4):217-25
pubmed: 16213224
Nat Rev Endocrinol. 2012 Apr 03;8(8):457-65
pubmed: 22473333
JAMA. 1999 Oct 27;282(16):1568-75
pubmed: 10546697
Front Endocrinol (Lausanne). 2015 Aug 31;6:136
pubmed: 26379628
Drug Discov Today. 2012 Jul;17(13-14):702-9
pubmed: 22342983
Cell Metab. 2013 May 7;17(5):638-43
pubmed: 23583169
Front Endocrinol (Lausanne). 2018 Nov 06;9:649
pubmed: 30459715
Cell Metab. 2013 Feb 5;17(2):236-48
pubmed: 23395170
Nat Med. 2004 May;10(5):524-9
pubmed: 15077108
Nature. 1996 Jan 4;379(6560):69-72
pubmed: 8538742
Nat Rev Endocrinol. 2017 Jun;13(6):324-337
pubmed: 28211512
Biochem Biophys Res Commun. 2005 Nov 11;337(1):248-55
pubmed: 16182246
Physiol Rev. 2004 Jan;84(1):277-359
pubmed: 14715917
Cell Metab. 2007 Jul;6(1):55-68
pubmed: 17618856
Nature. 2005 Jul 21;436(7049):356-62
pubmed: 16034410
Nat Med. 2017 Jul;23(7):839-849
pubmed: 28604703
Cell Metab. 2013 Sep 3;18(3):333-40
pubmed: 24011069
Endocrinology. 2010 Oct;151(10):4745-55
pubmed: 20826561
Immunity. 2018 May 15;48(5):992-1005.e8
pubmed: 29768180
Curr Opin Pharmacol. 2017 Jun;34:49-55
pubmed: 28605657
Cell. 2015 Dec 3;163(6):1360-74
pubmed: 26638070
Cell Metab. 2018 Aug 7;28(2):207-216.e3
pubmed: 29909972
Cell. 2007 Oct 19;131(2):242-56
pubmed: 17956727
Nat Med. 2019 Jan;25(1):165-175
pubmed: 30617325
Science. 2000 Sep 22;289(5487):2122-5
pubmed: 11000114
Cell Metab. 2016 Aug 9;24(2):332-40
pubmed: 27345423
Diabetes. 2004 Mar;53(3):577-84
pubmed: 14988240
Diabetes. 2001 Aug;50(8):1714-9
pubmed: 11473029
Nat Metab. 2019 Jan;1:16-33
pubmed: 31032474
Nature. 2002 Aug 8;418(6898):650-4
pubmed: 12167864
Ann N Y Acad Sci. 2008 Apr;1126:14-9
pubmed: 18448790
Nat Rev Cardiol. 2018 Dec;15(12):731-743
pubmed: 30115967
Cell Metab. 2016 Jun 14;23(6):1048-1059
pubmed: 27304506
Nat Rev Endocrinol. 2018 Jul;14(7):390-403
pubmed: 29728598
Nat Med. 2011 Jan;17(1):55-63
pubmed: 21186369
Brain Res. 2002 Feb 22;928(1-2):113-25
pubmed: 11844478
Nature. 2012 Nov 15;491(7424):357-63
pubmed: 23151578
J Gerontol A Biol Sci Med Sci. 2009 Sep;64(9):940-8
pubmed: 19483181
Nature. 1994 Dec 1;372(6505):425-32
pubmed: 7984236
Annu Rev Biochem. 1946;15:193-218
pubmed: 20995968
Cell Metab. 2018 Nov 6;28(5):750-763.e6
pubmed: 30122557
Cell Rep. 2016 Aug 23;16(8):2231-2242
pubmed: 27524625
Biology (Basel). 2017 Feb 04;6(1):
pubmed: 28165421
N Engl J Med. 2006 Jun 15;354(24):2552-63
pubmed: 16775236
Cell Metab. 2011 Jun 8;13(6):729-38
pubmed: 21641554
Nat Rev Mol Cell Biol. 2018 Oct;19(10):654-672
pubmed: 30104701
Elife. 2018 Sep 19;7:
pubmed: 30230471
Endocrinology. 2013 Jan;154(1):9-15
pubmed: 23183168
Cell. 2012 Oct 12;151(2):400-13
pubmed: 23063128
Cell Metab. 2007 Jun;5(6):426-37
pubmed: 17550778
Cell Metab. 2018 May 01;27(5):1138-1155.e6
pubmed: 29719227
Cell Metab. 2011 Oct 5;14(4):478-90
pubmed: 21982708
Expert Rev Proteomics. 2015 Jun;12(3):213-5
pubmed: 25925092
Nat Commun. 2015 May 12;6:7078
pubmed: 25963408
Nat Med. 1995 Dec;1(12):1311-4
pubmed: 7489415
Diabetes. 2009 Jan;58(1):250-9
pubmed: 18840786
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8
pubmed: 19541642
J Cell Biol. 2018 Jul 2;217(7):2273-2289
pubmed: 29622564
J Appl Physiol (1985). 2005 Apr;98(4):1154-62
pubmed: 15772055
Diabetes. 1961 May-Jun;10:232-4
pubmed: 13706674
J Pharm Sci. 1997 Mar;86(3):269-82
pubmed: 9050793
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3143-8
pubmed: 22315431
Diabetes. 2018 Jul;67(7):1246-1257
pubmed: 29712668
Sci Rep. 2019 Jan 24;9(1):630
pubmed: 30679672
Nat Med. 2017 Dec;23(12):1444-1453
pubmed: 29106398
Cold Spring Harb Perspect Med. 2017 Nov 1;7(11):
pubmed: 28389517
Diabetes. 2014 Feb;63(2):514-25
pubmed: 24150604
Cell. 2016 Jul 14;166(2):424-435
pubmed: 27374330
Diabetologia. 2015 Aug;58(8):1937-48
pubmed: 26040473
Cell. 2016 Apr 21;165(3):566-79
pubmed: 27087445
Annu Rev Nutr. 2018 Aug 21;38:173-196
pubmed: 29727594
Mol Metab. 2018 May;11:33-46
pubmed: 29650350
J Hered. 1950 Dec;41(12):317-8
pubmed: 14824537
Nat Rev Neurosci. 2018 Feb;19(2):95-105
pubmed: 29321684
Cell Metab. 2016 Sep 13;24(3):420-433
pubmed: 27626200
J Clin Invest. 2005 Jun;115(6):1627-35
pubmed: 15902306
Cell. 2018 Nov 29;175(6):1561-1574.e12
pubmed: 30449620
Mol Metab. 2013 Dec 27;3(3):221-9
pubmed: 24749049
Diabetes. 2014 Dec;63(12):3992-7
pubmed: 25414013
Nat Metab. 2019 Jan;1(1):34-46
pubmed: 32694818
Cell Metab. 2014 Mar 4;19(3):352-4
pubmed: 24606895
Nat Rev Endocrinol. 2017 Sep;13(9):509-520
pubmed: 28621339
Nature. 2000 Oct 19;407(6806):908-13
pubmed: 11057670
Cell Metab. 2017 Aug 1;26(2):375-393.e7
pubmed: 28768176
Genes Dev. 2013 Feb 1;27(3):234-50
pubmed: 23388824
Cell Metab. 2017 Sep 5;26(3):509-522.e6
pubmed: 28877455
Cell Metab. 2017 Apr 4;25(4):935-944.e4
pubmed: 28380381
Clin Sci (Lond). 2006 Feb;110(2):143-52
pubmed: 16411891
EMBO Rep. 2005 Jun;6(6):490-6
pubmed: 15940278
Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):143-9
pubmed: 20160646
J Nutr. 2015 Apr;145(4):672-80
pubmed: 25833771
Diabetes. 2010 Nov;59(11):2781-9
pubmed: 20682689
Science. 2011 Mar 25;331(6024):1621-4
pubmed: 21436455
Nat Rev Endocrinol. 2017 Jan;13(1):26-35
pubmed: 27616452
EMBO Rep. 2001 Apr;2(4):282-6
pubmed: 11306547
Cell. 2012 May 11;149(4):871-85
pubmed: 22579288
Trends Neurosci. 2017 Mar;40(3):167-180
pubmed: 28108113
Cell Metab. 2016 May 10;23(5):770-84
pubmed: 27166942
Nat Commun. 2018 Jan 16;9(1):245
pubmed: 29339725
Diabetes. 2014 Oct;63(10):3346-58
pubmed: 24917578
J Clin Endocrinol Metab. 2000 Nov;85(11):4003-9
pubmed: 11095423
Genes Dev. 2012 Feb 1;26(3):271-81
pubmed: 22302939
Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45
pubmed: 17972343
Nat Commun. 2015 May 12;6:7079
pubmed: 25963540
PLoS One. 2013 Apr 11;8(4):e60563
pubmed: 23593248