Lluis Fajas

Affiliations

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Department of Physiology, University of Lausanne, Lausanne, Switzerland.

Publications (20)

Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR.

PloS one

Avec: Daniel Castellano-Castillo , Pierre-Damien Denechaud , Lluis Fajas , Isabel Moreno-Indias , Wilfredo Oliva-Olivera , Francisco Tinahones , María Isabel Queipo-Ortuño , Fernando Cardona

Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor.

Frontiers in immunology

Avec: Tiia Snäkä , Amel Bekkar , Chantal Desponds , Florence Prével , Stéphanie Claudinot , Nathalie Isorce , Filipa Teixeira , Coline Grasset , Ioannis Xenarios , Isabel C Lopez-Mejia , Lluis Fajas , Nicolas Fasel

Beyond cell cycle regulation: the pleiotropic function of CDK4 in cancer.

Seminars in cancer biology

Avec: Dorian V Ziegler , Kanishka Parashar , Lluis Fajas

BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function.

iScience

Avec: Dogan Grepper , Cassandra Tabasso , Nadège Zanou , Axel K F Aguettaz , Mauricio Castro-Sepulveda , Dorian V Ziegler , Sylviane Lagarrigue , Yoan Arribat , Adrien Martinotti , Ammar Ebrahimi , Jean Daraspe , Lluis Fajas , Francesca Amati

Inter-organ communication: a gatekeeper for metabolic health.

EMBO reports

Avec: Judit Castillo-Armengol , Lluis Fajas , Isabel C Lopez-Mejia

CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival.

Cancer research

Avec: Laia Martínez-Carreres , Julien Puyal , Lucía C Leal-Esteban , Meritxell Orpinell , Judit Castillo-Armengol , Albert Giralt , Oleksandr Dergai , Catherine Moret , Valentin Barquissau , Anita Nasrallah , Angélique Pabois , Lianjun Zhang , Pedro Romero , Isabel C Lopez-Mejia , Lluis Fajas

The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer.

Cancers

Avec: Dorian V Ziegler , Katharina Huber , Lluis Fajas

E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells.

Biochimica et biophysica acta. Molecular cell research

Avec: Katharina Huber , Albert Giralt , René Dreos , Helene Michenthaler , Sarah Geller , Valentin Barquissau , Dorian V Ziegler , Daniele Tavernari , Hector Gallart-Ayala , Katarina Krajina , Katharina Jonas , Giovanni Ciriello , Julijana Ivanisevic , Andreas Prokesch , Martin Pichler , Lluis Fajas

PamgeneAnalyzeR: open and reproducible pipeline for kinase profiling.

Bioinformatics (Oxford, England)

Avec: Amel Bekkar , Anita Nasrallah , Nicolas Guex , Lluis Fajas , Ioannis Xenarios , Isabel C Lopez-Mejia

Cell cycle regulators in cancer cell metabolism.

Biochimica et biophysica acta. Molecular basis of disease

Avec: Lucia C Leal-Esteban , Lluis Fajas

The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.

Nature communications

Avec: Matthieu Lacroix , Laetitia K Linares , Natalia Rueda-Rincon , Katarzyna Bloch , Michela Di Michele , Carlo De Blasio , Caroline Fau , Laurie Gayte , Emilie Blanchet , Aline Mairal , Rita Derua , Fernando Cardona , Diane Beuzelin , Jean-Sebastien Annicotte , Nelly Pirot , Adeline Torro , Francisco J Tinahones , Florence Bernex , Justine Bertrand-Michel , Dominique Langin , Lluis Fajas , Johannes V Swinnen , Laurent Le Cam

Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation.

Cells

Avec: Abrar Ul Haq Khan , Hamideh Salehi , Catherine Alexia , Jose M Valdivielso , Milica Bozic , Isabel C Lopez-Mejia , Lluis Fajas , Sabine Gerbal-Chaloin , Martine Daujat-Chavanieu , Delphine Gitenay , Martin Villalba

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Laura Esteban-Burgos , Haiyun Wang , Patricia Nieto , Jie Zheng , Carmen Blanco-Aparicio , Carmen Varela , Gonzalo Gómez-López , Fernando Fernández-García , Manuel Sanclemente , Carmen Guerra , Matthias Drosten , Javier Galán , Eduardo Caleiras , Jorge Martínez-Torrecuadrada , Lluis Fajas , Sheng-Bin Peng , David Santamaría , Monica Musteanu , Mariano Barbacid

The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.

The FEBS journal

Avec: Katharina Huber , Alberto Mestres-Arenas , Lluis Fajas , Lucia C Leal-Esteban

Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness.

Molecular oncology

Avec: Isabel C Lopez-Mejia , Jordi Pijuan , Raúl Navaridas , Maria Santacana , Sònia Gatius , Ana Velasco , Gerard Castellà , Anaïs Panosa , Elisa Cabiscol , Miquel Pinyol , Laura Coll , Núria Bonifaci , Laura Plata Peña , August Vidal , Alberto Villanueva , Eloi Gari , David Llobet-Navàs , Lluis Fajas , Xavier Matias-Guiu , Andrée Yeramian

Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues.

EMBO reports

Avec: Judit Castillo-Armengol , Valentin Barquissau , Sarah Geller , Honglei Ji , Ilenia Severi , Wiebe Venema , Eric Aria Fenandez , Catherine Moret , Katharina Huber , Lucia C Leal-Esteban , Anita Nasrallah , Laia Martinez-Carreres , Guy Niederhäuser , Patricia Seoane-Collazo , Sylviane Lagarrigue , Miguel López , Antonio Giordano , Sophie Croizier , Bernard Thorens , Isabel C Lopez-Mejia , Lluis Fajas

CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.

iScience

Avec: Honglei Ji , Yizhe Chen , Judit Castillo-Armengol , René Dreos , Catherine Moret , Guy Niederhäuser , Brigitte Delacuisine , Isabel C Lopez-Mejia , Pierre-Damien Denechaud , Lluis Fajas

Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity.

Cellular & molecular immunology

Avec: Nina Dumauthioz , Benjamin Tschumi , Mathias Wenes , Bastien Marti , Haiping Wang , Fabien Franco , Wenhui Li , Isabel C Lopez-Mejia , Lluis Fajas , Ping-Chih Ho , Alena Donda , Pedro Romero , Lianjun Zhang

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs.

eLife

Avec: Ece Yildiz , Gaby El Alam , Alessia Perino , Antoine Jalil , Pierre-Damien Denechaud , Katharina Huber , Lluis Fajas , Johan Auwerx , Giovanni Sorrentino , Kristina Schoonjans

β-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion.

Diabetes

Avec: Frédérik Oger , Cyril Bourouh , Marika Elsa Friano , Emilie Courty , Laure Rolland , Xavier Gromada , Maeva Moreno , Charlène Carney , Nabil Rabhi , Emmanuelle Durand , Souhila Amanzougarene , Lionel Berberian , Mehdi Derhourhi , Etienne Blanc , Sarah Anissa Hannou , Pierre-Damien Denechaud , Zohra Benfodda , Patrick Meffre , Lluis Fajas , Julie Kerr-Conte , François Pattou , Philippe Froguel , Benoit Pourcet , Amélie Bonnefond , Patrick Collombat , Jean-Sébastien Annicotte

Réseau de co-auteurs

Isabel C Lopez-Mejia 9 collaborations

Katharina Huber 5 collaborations

Pierre-Damien Denechaud 4 collaborations

Dorian V Ziegler 4 collaborations

Judit Castillo-Armengol 4 collaborations

Catherine Moret 3 collaborations

Valentin Barquissau 3 collaborations

Anita Nasrallah 3 collaborations

Lucia C Leal-Esteban 3 collaborations

Fernando Cardona 2 collaborations

Amel Bekkar 2 collaborations

Ioannis Xenarios 2 collaborations

Sylviane Lagarrigue 2 collaborations

Albert Giralt 2 collaborations

Lianjun Zhang 2 collaborations

Pedro Romero 2 collaborations

René Dreos 2 collaborations

Sarah Geller 2 collaborations

Honglei Ji 2 collaborations

Guy Niederhäuser 2 collaborations

Daniel Castellano-Castillo 1 collaboration

Isabel Moreno-Indias 1 collaboration

Wilfredo Oliva-Olivera 1 collaboration

Francisco Tinahones 1 collaboration

María Isabel Queipo-Ortuño 1 collaboration

Tiia Snäkä 1 collaboration

Chantal Desponds 1 collaboration

Florence Prével 1 collaboration

Stéphanie Claudinot 1 collaboration

Nathalie Isorce 1 collaboration

Filipa Teixeira 1 collaboration

Coline Grasset 1 collaboration

Nicolas Fasel 1 collaboration

Kanishka Parashar 1 collaboration

Dogan Grepper 1 collaboration

Cassandra Tabasso 1 collaboration

Nadège Zanou 1 collaboration

Axel K F Aguettaz 1 collaboration

Mauricio Castro-Sepulveda 1 collaboration

Yoan Arribat 1 collaboration

Adrien Martinotti 1 collaboration

Ammar Ebrahimi 1 collaboration

Jean Daraspe 1 collaboration

Francesca Amati 1 collaboration

Laia Martínez-Carreres 1 collaboration

Julien Puyal 1 collaboration

Lucía C Leal-Esteban 1 collaboration

Meritxell Orpinell 1 collaboration

Oleksandr Dergai 1 collaboration

Angélique Pabois 1 collaboration

Helene Michenthaler 1 collaboration

Daniele Tavernari 1 collaboration

Hector Gallart-Ayala 1 collaboration

Katarina Krajina 1 collaboration

Katharina Jonas 1 collaboration

Giovanni Ciriello 1 collaboration

Julijana Ivanisevic 1 collaboration

Andreas Prokesch 1 collaboration

Martin Pichler 1 collaboration

Nicolas Guex 1 collaboration

Matthieu Lacroix 1 collaboration

Laetitia K Linares 1 collaboration

Natalia Rueda-Rincon 1 collaboration

Katarzyna Bloch 1 collaboration

Michela Di Michele 1 collaboration

Carlo De Blasio 1 collaboration

Caroline Fau 1 collaboration

Laurie Gayte 1 collaboration

Emilie Blanchet 1 collaboration

Aline Mairal 1 collaboration

Rita Derua 1 collaboration

Diane Beuzelin 1 collaboration

Jean-Sebastien Annicotte 1 collaboration

Nelly Pirot 1 collaboration

Adeline Torro 1 collaboration

Francisco J Tinahones 1 collaboration

Florence Bernex 1 collaboration

Justine Bertrand-Michel 1 collaboration

Dominique Langin 1 collaboration

Johannes V Swinnen 1 collaboration

Laurent Le Cam 1 collaboration

Abrar Ul Haq Khan 1 collaboration

Hamideh Salehi 1 collaboration

Catherine Alexia 1 collaboration

Jose M Valdivielso 1 collaboration

Milica Bozic 1 collaboration

Sabine Gerbal-Chaloin 1 collaboration

Martine Daujat-Chavanieu 1 collaboration

Delphine Gitenay 1 collaboration

Martin Villalba 1 collaboration

Laura Esteban-Burgos 1 collaboration

Haiyun Wang 1 collaboration

Patricia Nieto 1 collaboration

Jie Zheng 1 collaboration

Carmen Blanco-Aparicio 1 collaboration

Carmen Varela 1 collaboration

Gonzalo Gómez-López 1 collaboration

Fernando Fernández-García 1 collaboration

Manuel Sanclemente 1 collaboration

Carmen Guerra 1 collaboration

Matthias Drosten 1 collaboration

Javier Galán 1 collaboration

Eduardo Caleiras 1 collaboration

Jorge Martínez-Torrecuadrada 1 collaboration

Sheng-Bin Peng 1 collaboration

David Santamaría 1 collaboration

Monica Musteanu 1 collaboration

Mariano Barbacid 1 collaboration

Alberto Mestres-Arenas 1 collaboration

Jordi Pijuan 1 collaboration

Raúl Navaridas 1 collaboration

Maria Santacana 1 collaboration

Sònia Gatius 1 collaboration

Ana Velasco 1 collaboration

Gerard Castellà 1 collaboration

Anaïs Panosa 1 collaboration

Elisa Cabiscol 1 collaboration

Miquel Pinyol 1 collaboration

Laura Coll 1 collaboration

Núria Bonifaci 1 collaboration

Laura Plata Peña 1 collaboration

August Vidal 1 collaboration

Alberto Villanueva 1 collaboration

Eloi Gari 1 collaboration

David Llobet-Navàs 1 collaboration

Xavier Matias-Guiu 1 collaboration

Andrée Yeramian 1 collaboration

Ilenia Severi 1 collaboration

Wiebe Venema 1 collaboration

Eric Aria Fenandez 1 collaboration

Laia Martinez-Carreres 1 collaboration

Patricia Seoane-Collazo 1 collaboration

Miguel López 1 collaboration

Antonio Giordano 1 collaboration

Sophie Croizier 1 collaboration

Bernard Thorens 1 collaboration

Yizhe Chen 1 collaboration

Brigitte Delacuisine 1 collaboration

Nina Dumauthioz 1 collaboration

Benjamin Tschumi 1 collaboration

Mathias Wenes 1 collaboration

Bastien Marti 1 collaboration

Haiping Wang 1 collaboration

Fabien Franco 1 collaboration

Wenhui Li 1 collaboration

Ping-Chih Ho 1 collaboration

Alena Donda 1 collaboration

Ece Yildiz 1 collaboration

Gaby El Alam 1 collaboration

Alessia Perino 1 collaboration

Antoine Jalil 1 collaboration

Johan Auwerx 1 collaboration

Giovanni Sorrentino 1 collaboration

Kristina Schoonjans 1 collaboration

Frédérik Oger 1 collaboration

Cyril Bourouh 1 collaboration

Marika Elsa Friano 1 collaboration

Emilie Courty 1 collaboration

Laure Rolland 1 collaboration

Xavier Gromada 1 collaboration

Maeva Moreno 1 collaboration

Charlène Carney 1 collaboration

Nabil Rabhi 1 collaboration

Emmanuelle Durand 1 collaboration

Souhila Amanzougarene 1 collaboration

Lionel Berberian 1 collaboration

Mehdi Derhourhi 1 collaboration

Etienne Blanc 1 collaboration

Sarah Anissa Hannou 1 collaboration

Zohra Benfodda 1 collaboration

Patrick Meffre 1 collaboration

Julie Kerr-Conte 1 collaboration

François Pattou 1 collaboration

Philippe Froguel 1 collaboration

Benoit Pourcet 1 collaboration

Amélie Bonnefond 1 collaboration

Patrick Collombat 1 collaboration

Jean-Sébastien Annicotte 1 collaboration