The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.

Adipocytes / metabolism Adipose Tissue / metabolism Adult Aged Animals Body Mass Index Fatty Acids, Monounsaturated / metabolism Female Gene Expression Regulation Humans Insulin Resistance Lipid Metabolism / genetics Male Mice Mice, Knockout Middle Aged Obesity / genetics Repressor Proteins / deficiency Signal Transduction Stearoyl-CoA Desaturase / genetics Tumor Suppressor Protein p53 / genetics Ubiquitin-Protein Ligases / deficiency

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
02 12 2021
Historique:
received: 12 08 2016
accepted: 12 11 2021
entrez: 3 12 2021
pubmed: 4 12 2021
medline: 5 1 2022
Statut: epublish

Résumé

Growing evidence supports the importance of the p53 tumor suppressor in metabolism but the mechanisms underlying p53-mediated control of metabolism remain poorly understood. Here, we identify the multifunctional E4F1 protein as a key regulator of p53 metabolic functions in adipocytes. While E4F1 expression is upregulated during obesity, E4f1 inactivation in mouse adipose tissue results in a lean phenotype associated with insulin resistance and protection against induced obesity. Adipocytes lacking E4F1 activate a p53-dependent transcriptional program involved in lipid metabolism. The direct interaction between E4F1 and p53 and their co-recruitment to the Steaoryl-CoA Desaturase-1 locus play an important role to regulate monounsaturated fatty acids synthesis in adipocytes. Consistent with the role of this E4F1-p53-Steaoryl-CoA Desaturase-1 axis in adipocytes, p53 inactivation or diet complementation with oleate partly restore adiposity and improve insulin sensitivity in E4F1-deficient mice. Altogether, our findings identify a crosstalk between E4F1 and p53 in the control of lipid metabolism in adipocytes that is relevant to obesity and insulin resistance.

Identifiants

DOI: 10.1038/s41467-021-27307-3 PMID: 34857760 PMC: PMC8639890
pubmed: 34857760
doi: 10.1038/s41467-021-27307-3
pii: 10.1038/s41467-021-27307-3
pmc: PMC8639890
doi:

Substances chimiques

Fatty Acids, Monounsaturated 0
Repressor Proteins 0
Tumor Suppressor Protein p53 0
Stearoyl-CoA Desaturase EC 1.14.19.1
E4F1 protein, human EC 2.3.2.27
E4f1 protein, mouse EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7037

Informations de copyright

© 2021. The Author(s).

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Auteurs

Matthieu Lacroix (M)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
Equipe labélisée Ligue Contre le Cancer, Paris, France.
ORCID: 0000-0002-1268-9058

Laetitia K Linares (LK)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
Equipe labélisée Ligue Contre le Cancer, Paris, France.

Natalia Rueda-Rincon (N)

KU Leuven-University of Leuven, Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, Belgium.

Katarzyna Bloch (K)

KU Leuven-University of Leuven, Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, Belgium.

Michela Di Michele (M)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
Equipe labélisée Ligue Contre le Cancer, Paris, France.

Carlo De Blasio (C)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
Equipe labélisée Ligue Contre le Cancer, Paris, France.
ORCID: 0000-0003-2388-2555

Caroline Fau (C)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
Equipe labélisée Ligue Contre le Cancer, Paris, France.

Laurie Gayte (L)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
Equipe labélisée Ligue Contre le Cancer, Paris, France.

Emilie Blanchet (E)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.

Aline Mairal (A)

I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.

Rita Derua (R)

KU Leuven-University of Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium.

Fernando Cardona (F)

Department of Surgical Specialties, Biochemistry and Immunology School of Medicine, University of Malaga, Malaga, Spain.
ORCID: 0000-0003-4460-6824

Diane Beuzelin (D)

I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.

Jean-Sebastien Annicotte (JS)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, Lille, France.
ORCID: 0000-0002-2109-4849

Nelly Pirot (N)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
BioCampus, RHEM, Université de Montpellier, CNRS, INSERM, Montpellier, France.

Adeline Torro (A)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.

Francisco J Tinahones (FJ)

CIBER of Physiopathology, Obesity and Nutrition (CIBEROBN), Málaga, Spain; Unidad de Gestion Clinica de Endocrinologia y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clinico Virgen de la Victoria, Málaga, Spain.

Florence Bernex (F)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
BioCampus, RHEM, Université de Montpellier, CNRS, INSERM, Montpellier, France.

Justine Bertrand-Michel (J)

I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.

Dominique Langin (D)

I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, INSERM, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.
Toulouse University Hospitals, Department of Clinical Biochemistry, Toulouse, France.
ORCID: 0000-0002-2669-7825

Lluis Fajas (L)

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0002-1283-9503

Johannes V Swinnen (JV)

KU Leuven-University of Leuven, Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, Belgium.
ORCID: 0000-0002-7720-5077

Laurent Le Cam (L)

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Univ Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France. laurent.lecam@inserm.fr.
Equipe labélisée Ligue Contre le Cancer, Paris, France. laurent.lecam@inserm.fr.
ORCID: 0000-0003-0325-878X

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Eucaryotes › Animaux › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Acyl-(acyl-carrier-protein)desaturase › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › The multifunctional protein E4F1 links P53 to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › The multifunctional protein E4F1 links P53 to...