Nordic OCD & Related Disorders Consortium: Rationale, design, and methods.
Denmark
GWAS
Norway
OCD
Sweden
genetic
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
24
02
2019
revised:
19
07
2019
accepted:
29
07
2019
pubmed:
20
8
2019
medline:
5
1
2021
entrez:
20
8
2019
Statut:
ppublish
Résumé
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology is unknown and treatment outcomes could be improved if biological targets could be identified. Unfortunately, genetic findings for OCD are lagging behind other psychiatric disorders. Thus, there is a pressing need to understand the causal mechanisms implicated in OCD in order to improve clinical outcomes and to reduce morbidity and societal costs. Specifically, there is a need for a large-scale, etiologically informative genetic study integrating genetic and environmental factors that presumably interact to cause the condition. The Nordic countries provide fertile ground for such a study, given their detailed population registers, national healthcare systems and active specialist clinics for OCD. We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the support of NIMH and the Swedish Research Council, have begun to collect a large, richly phenotyped and genotyped sample of OCD cases. Our specific aims are geared toward answering a number of key questions regarding the biology, etiology, and treatment of OCD. This article describes and discusses the rationale, design, and methodology of NORDiC, including details on clinical measures and planned genomic analyses.
Identifiants
pubmed: 31424634
doi: 10.1002/ajmg.b.32756
pmc: PMC6898732
mid: NIHMS1045070
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-50Subventions
Organisme : NIMH NIH HHS
ID : R01 MH105500
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110427
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH109938
Pays : United States
Organisme : Vetenskapsrådet
ID : 2015-02271
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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