Management of Diarrhea in Patients With Carcinoid Syndrome.
Cost-Benefit Analysis
Diagnosis, Differential
Diarrhea
/ etiology
Humans
Intestinal Neoplasms
/ complications
Malignant Carcinoid Syndrome
/ complications
Neuroendocrine Tumors
/ complications
Pancreatic Neoplasms
/ complications
Quality of Life
Somatostatin
/ analogs & derivatives
Stomach Neoplasms
/ complications
Journal
Pancreas
ISSN: 1536-4828
Titre abrégé: Pancreas
Pays: United States
ID NLM: 8608542
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
entrez:
20
8
2019
pubmed:
20
8
2019
medline:
28
7
2020
Statut:
ppublish
Résumé
Neuroendocrine tumors (NETs) arise from enterochromaffin cells found in neuroendocrine tissues, with most occurring in the gastrointestinal tract. The global incidence of NETs has increased in the past 15 years, likely due to better diagnostic methods. Small-bowel NETs are frequently associated with carcinoid syndrome (CS). Carcinoid syndrome diarrhea occurs in 80% of CS patients and poses a substantial symptomatic and economic burden. Patients with CS diarrhea frequently suffer from diarrhea and flushing and report corresponding impairment in quality of life, requiring substantial changes in daily activities and lifestyle. Treatment paradigms range from surgical debulking to liver-directed therapies to treatment with somatostatin analogs, nonspecific anti-diarrheal agents, and a tryptophan hydroxylase inhibitor. Other causes of diarrhea, including steatorrhea, short bowel syndrome, and bile acid malabsorption, should be considered in NET patients with refractory diarrhea. More therapeutic options are needed for symptomatic management of patients with NETs, and better understanding of the pathophysiology can empower clinicians with improved patient care.
Identifiants
pubmed: 31425482
doi: 10.1097/MPA.0000000000001384
pii: 00006676-201909000-00002
pmc: PMC6867674
doi:
Substances chimiques
Somatostatin
51110-01-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
961-972Subventions
Organisme : NCI NIH HHS
ID : P50 CA174521
Pays : United States
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