Short-term hypoxia promotes vascularization in co-culture system consisting of primary human osteoblasts and outgrowth endothelial cells.
bone engineering
hypoxia
outgrowth endothelial cell
primary osteoblast
vascularization/angiogenesis
Journal
Journal of biomedical materials research. Part A
ISSN: 1552-4965
Titre abrégé: J Biomed Mater Res A
Pays: United States
ID NLM: 101234237
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
05
06
2019
revised:
08
08
2019
accepted:
12
08
2019
pubmed:
21
8
2019
medline:
10
6
2021
entrez:
21
8
2019
Statut:
ppublish
Résumé
Prevascularization of tissue constructs before implantation has been developed as a novel and promising concept for successful implantation. Since hypoxia might induce angiogenesis, we have investigated the effects of hypoxic treatment on vascularization by using co-cultures of primary human osteoblasts (POBs) and outgrowth endothelial cells. Our results show that: (a) repeated short-term hypoxia (2% O
Substances chimiques
Inflammation Mediators
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-18Informations de copyright
© 2019 Wiley Periodicals, Inc.
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