Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
12
01
2019
accepted:
17
07
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
28
2
2020
Statut:
epublish
Résumé
The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying genetic variants associated with psychiatric disorders, most variants have small individual contributions to risk. By contrast, disease risk increase appears to be less subtle for disease-predisposing environmental insults. In this study, we sought to identify associations between environmental pollution and risk of neuropsychiatric disorders. We present exploratory analyses of 2 independent, very large datasets: 151 million unique individuals, represented in a United States insurance claims dataset, and 1.4 million unique individuals documented in Danish national treatment registers. Environmental Protection Agency (EPA) county-level environmental quality indices (EQIs) in the US and individual-level exposure to air pollution in Denmark were used to assess the association between pollution exposure and the risk of neuropsychiatric disorders. These results show that air pollution is significantly associated with increased risk of psychiatric disorders. We hypothesize that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.
Identifiants
pubmed: 31430271
doi: 10.1371/journal.pbio.3000353
pii: PBIOLOGY-D-19-00092
pmc: PMC6701746
doi:
Substances chimiques
Environmental Pollutants
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000353Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094267
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122712
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL108634
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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