The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
03 10 2019
03 10 2019
Historique:
received:
29
03
2019
accepted:
09
08
2019
pubmed:
23
8
2019
medline:
1
2
2020
entrez:
23
8
2019
Statut:
ppublish
Résumé
KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential side effects of continuous inhibition of these enzymes. Utilizing conditional
Identifiants
pubmed: 31434704
pii: S0006-4971(20)70773-1
doi: 10.1182/blood.2019000855
pmc: PMC6776794
doi:
Substances chimiques
Histones
0
Histone Demethylases
EC 1.14.11.-
JMJD2A protein, mouse
EC 1.14.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1154-1158Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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