Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.
Antifungal Agents
/ therapeutic use
Aspergillus fumigatus
/ isolation & purification
Diagnosis, Differential
Fatal Outcome
Humans
Immunocompromised Host
Leukemia, Myeloid, Acute
Male
Middle Aged
Nitriles
/ therapeutic use
Pulmonary Aspergillosis
/ diagnosis
Pyridines
/ therapeutic use
Treatment Failure
Triazoles
/ therapeutic use
Aspergillus fumigatus
CT
France
Rhizomucor
acute myeloid leukemia
antimicrobial resistance
aspergillosis
computed tomography
death
fungal co-infection
fungi
galactomannan antigen
graft-versus-host disease
hematopoietic stem-cell transplantation
immunocompromised patients
invasive fungal disease
isavuconazole
mucormycosis
qPCR
quantitative PCR
treatment failure
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
30
1
2020
Statut:
ppublish
Résumé
We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.
Identifiants
pubmed: 31441760
doi: 10.3201/eid2509.190598
pmc: PMC6711214
doi:
Substances chimiques
Antifungal Agents
0
Nitriles
0
Pyridines
0
Triazoles
0
isavuconazole
60UTO373KE
Types de publication
Case Reports
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
1778-1779Références
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