Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.

3-Hydroxybutyric Acid / blood Aged, 80 and over Animals Cell Differentiation / drug effects Cell Self Renewal Diet, High-Fat Female Histone Deacetylase Inhibitors / pharmacology Humans Hydroxymethylglutaryl-CoA Synthase / deficiency Intestines / cytology Ketone Bodies / metabolism Male Mice Mice, Knockout Receptors, G-Protein-Coupled / metabolism Receptors, Notch / metabolism Signal Transduction / drug effects Stem Cells / cytology Young Adult
HDAC Hmgcs2 Intestinal stem cell Notch beta-hydroxybutyrate ketogenic diet ketone bodies

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
22 08 2019
Historique:
received: 07 01 2019
revised: 03 06 2019
accepted: 25 07 2019
entrez: 24 8 2019
pubmed: 24 8 2019
medline: 12 5 2020
Statut: ppublish

Résumé

Little is known about how metabolites couple tissue-specific stem cell function with physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies, including beta-hydroxybutyrate (βOHB), distinguishes self-renewing Lgr5

Identifiants

DOI: 10.1016/j.cell.2019.07.048 PMID: 31442404 PMC: PMC6732196
pubmed: 31442404
pii: S0092-8674(19)30848-7
doi: 10.1016/j.cell.2019.07.048
pmc: PMC6732196
mid: NIHMS1536380
pii:
doi:

Substances chimiques

Histone Deacetylase Inhibitors 0
Ketone Bodies 0
Lgr5 protein, mouse 0
Receptors, G-Protein-Coupled 0
Receptors, Notch 0
HMGCS2 protein, mouse EC 2.3.3.10
Hydroxymethylglutaryl-CoA Synthase EC 2.3.3.10
3-Hydroxybutyric Acid TZP1275679

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1115-1131.e15

Subventions

Organisme : NIDDK NIH HHS
ID : R00 DK123407
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK123407
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG054760
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA163109
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009216
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224068
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG054760
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207236
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG045144
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA034992
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211184
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Chia-Wei Cheng (CW)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Moshe Biton (M)

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Adam L Haber (AL)

Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Nuray Gunduz (N)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University, 06800 Ankara, Turkey.

George Eng (G)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.

Liam T Gaynor (LT)

Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Surya Tripathi (S)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Gizem Calibasi-Kocal (G)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey.

Steffen Rickelt (S)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Vincent L Butty (VL)

BioMicro Center at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.

Marta Moreno-Serrano (M)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Ameena M Iqbal (AM)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Khristian E Bauer-Rowe (KE)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Shinya Imada (S)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Mehmet Sefa Ulutas (MS)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, Siirt University, Science and Arts Faculty, 56100 Siirt, Turkey.

Constantine Mylonas (C)

Department of Biology, MIT, Cambridge, MA 02139, USA.

Mark T Whary (MT)

Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

Stuart S Levine (SS)

BioMicro Center at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.

Yasemin Basbinar (Y)

Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey.

Richard O Hynes (RO)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.

Mari Mino-Kenudson (M)

Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.

Vikram Deshpande (V)

Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.

Laurie A Boyer (LA)

Department of Biology, MIT, Cambridge, MA 02139, USA.

James G Fox (JG)

Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

Christopher Terranova (C)

Genomic Medicine Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Kunal Rai (K)

Genomic Medicine Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Helen Piwnica-Worms (H)

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Maria M Mihaylova (MM)

Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210 USA.

Aviv Regev (A)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.

Ömer H Yilmaz (ÖH)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ohyilmaz@mit.edu.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Butyrates › Hydroxy-butyrates › Acide 3-hydroxy-butyrique › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Auto-renouvellement cellulaire › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Hydroxymethylglutaryl-coA synthase › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Corps cétoniques › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Cellules › Cellules souches › Ketone Body Signaling Mediates Intestinal Stem...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Ketone Body Signaling Mediates Intestinal Stem...