Atopic dermatitis and risk of atrial fibrillation or flutter: A 35-year follow-up study.
Adolescent
Adult
Atrial Fibrillation
/ epidemiology
Child
Child, Preschool
Denmark
/ epidemiology
Dermatitis, Atopic
/ diagnosis
Female
Follow-Up Studies
Humans
Incidence
Infant
Inflammation
/ diagnosis
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Registries
/ statistics & numerical data
Risk Assessment
/ statistics & numerical data
Risk Factors
Severity of Illness Index
Skin
/ immunology
Young Adult
atopic dermatitis
atrial fibrillation
atrial flutter
cohort study
risk factors
validation
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
11
2018
revised:
26
07
2019
accepted:
14
08
2019
pubmed:
24
8
2019
medline:
24
4
2021
entrez:
24
8
2019
Statut:
ppublish
Résumé
Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation. To examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation. Using linked population-based Danish registries, we identified persons with an inpatient or outpatient hospital diagnosis of atopic dermatitis during 1977-2013 and a comparison cohort individually matched to the atopic dermatitis cohort. We followed cohorts until death, emigration, atrial fibrillation diagnosis, or end of study (January 1, 2013). We compared 35-year risk of atrial fibrillation and estimated hazard ratios with 95% confidence intervals using Cox regression, adjusting for birth year and sex. We validated 100 atopic dermatitis diagnoses from a dermatologic department through medical record review. We included 13,126 persons with atopic dermatitis and 124,211 comparators and followed them for a median of 19.3 years. The 35-year risk of atrial fibrillation was 0.81% and 0.67%, respectively. The positive predictive value of atopic dermatitis diagnoses was 99%. The hazard ratio was 1.2 (95% confidence interval 1.0-1.6) and remained increased after adjusting for various atrial fibrillation risk factors. Analyses were limited to persons with moderate-to-severe atopic dermatitis, and we had no lifestyle data. Patients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low.
Sections du résumé
BACKGROUND
BACKGROUND
Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation.
OBJECTIVE
OBJECTIVE
To examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation.
METHODS
METHODS
Using linked population-based Danish registries, we identified persons with an inpatient or outpatient hospital diagnosis of atopic dermatitis during 1977-2013 and a comparison cohort individually matched to the atopic dermatitis cohort. We followed cohorts until death, emigration, atrial fibrillation diagnosis, or end of study (January 1, 2013). We compared 35-year risk of atrial fibrillation and estimated hazard ratios with 95% confidence intervals using Cox regression, adjusting for birth year and sex. We validated 100 atopic dermatitis diagnoses from a dermatologic department through medical record review.
RESULTS
RESULTS
We included 13,126 persons with atopic dermatitis and 124,211 comparators and followed them for a median of 19.3 years. The 35-year risk of atrial fibrillation was 0.81% and 0.67%, respectively. The positive predictive value of atopic dermatitis diagnoses was 99%. The hazard ratio was 1.2 (95% confidence interval 1.0-1.6) and remained increased after adjusting for various atrial fibrillation risk factors.
LIMITATIONS
CONCLUSIONS
Analyses were limited to persons with moderate-to-severe atopic dermatitis, and we had no lifestyle data.
CONCLUSION
CONCLUSIONS
Patients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low.
Identifiants
pubmed: 31442537
pii: S0190-9622(19)32614-3
doi: 10.1016/j.jaad.2019.08.039
pmc: PMC7704103
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1616-1624Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 205039/Z/16/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
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