Expression of THSD7A in neoplasm tissues and its relationship with proteinuria.
Breast cancer
Colorectal cancer
Membranous nephropathy
Proteinuria
Thrombospondin type 1 domain containing 7A
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
23 08 2019
23 08 2019
Historique:
received:
03
03
2019
accepted:
25
07
2019
entrez:
25
8
2019
pubmed:
25
8
2019
medline:
5
11
2020
Statut:
epublish
Résumé
Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies. THSD7A was found to be expressed in a variety of malignant tumors. In this study, we investigated the histologic expression of THSD7A in colorectal or breast cancers, as well as the relationship between THSD7A expression and proteinuria in the patients with cancers. A total of 101 patients were enrolled in the study, 81 of them had colorectal cancer and 20 had breast cancer. THSD7A expression was detected by immunohistochemical staining in tumor tissues. The clinical and laboratory parameters of these patients before their tumor resection were collected. Positive expression rates of THSD7A in the two types of tumor tissues were very high, 97.5% in colorectal cancer, and 100% in breast cancer. THSD7A expression was also detected in lymph nodes of two patients with lymph node metastasis. Total 11 patients (10.9%) had proteinuria before surgery. Among the 4 patients who had proteinuria and were followed up, the proteinuria of 3 patients disappeared after surgery. The positive rate of THSD7A expression was very high in human colorectal cancer or breast cancer. It might be an important link between malignant tumors and kidney diseases.
Sections du résumé
BACKGROUND
Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies. THSD7A was found to be expressed in a variety of malignant tumors. In this study, we investigated the histologic expression of THSD7A in colorectal or breast cancers, as well as the relationship between THSD7A expression and proteinuria in the patients with cancers.
METHOD
A total of 101 patients were enrolled in the study, 81 of them had colorectal cancer and 20 had breast cancer. THSD7A expression was detected by immunohistochemical staining in tumor tissues. The clinical and laboratory parameters of these patients before their tumor resection were collected.
RESULTS
Positive expression rates of THSD7A in the two types of tumor tissues were very high, 97.5% in colorectal cancer, and 100% in breast cancer. THSD7A expression was also detected in lymph nodes of two patients with lymph node metastasis. Total 11 patients (10.9%) had proteinuria before surgery. Among the 4 patients who had proteinuria and were followed up, the proteinuria of 3 patients disappeared after surgery.
CONCLUSIONS
The positive rate of THSD7A expression was very high in human colorectal cancer or breast cancer. It might be an important link between malignant tumors and kidney diseases.
Identifiants
pubmed: 31443644
doi: 10.1186/s12882-019-1489-5
pii: 10.1186/s12882-019-1489-5
pmc: PMC6708223
doi:
Substances chimiques
THSD7A protein, human
0
Thrombospondins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
332Références
Nature. 2000 Sep 14;407(6801):249-57
pubmed: 11001068
N Engl J Med. 2002 Jun 27;346(26):2053-60
pubmed: 12087141
J Clin Invest. 1959 Jan 1;38(1, Part 1):186-92
pubmed: 13620781
N Engl J Med. 2009 Jul 2;361(1):11-21
pubmed: 19571279
Kidney Int. 2010 May;77(9):765-70
pubmed: 20182413
Semin Nephrol. 2010 Nov;30(6):635-44
pubmed: 21146128
N Engl J Med. 2011 Feb 17;364(7):689-90
pubmed: 21323563
Dev Dyn. 2011 Jun;240(6):1412-21
pubmed: 21520329
PLoS One. 2011;6(12):e29000
pubmed: 22194972
Lancet. 2012 Jul 21;380(9838):213-4; author reply 214-6
pubmed: 22817966
N Engl J Med. 2014 Dec 11;371(24):2277-2287
pubmed: 25394321
PLoS One. 2015 Sep 22;10(9):e0138841
pubmed: 26393352
Mod Pathol. 2016 Apr;29(4):421-6
pubmed: 26847174
N Engl J Med. 2016 May 19;374(20):1995-6
pubmed: 27192690
J Clin Invest. 2016 Jul 1;126(7):2519-32
pubmed: 27214550
J Am Soc Nephrol. 2017 Feb;28(2):520-531
pubmed: 27436855
Genes Chromosomes Cancer. 2017 Apr;56(4):314-327
pubmed: 28035718
J Am Soc Nephrol. 2017 Sep;28(9):2579-2589
pubmed: 28674044
Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1642-1651
pubmed: 28801527
Oncotarget. 2017 Apr 8;8(36):60539-60557
pubmed: 28947992
Ren Fail. 2018 Nov;40(1):306-313
pubmed: 29623759
Nat Med. 1995 Jan;1(1):27-31
pubmed: 7584949