Pore-modulating toxins exploit inherent slow inactivation to block K
Animals
Cell Membrane
/ drug effects
Crystallography, X-Ray
Drosophila Proteins
/ antagonists & inhibitors
Drug Design
Female
Hydrogen Bonding
/ drug effects
Ion Channel Gating
/ drug effects
Kv1.2 Potassium Channel
/ antagonists & inhibitors
Lethal Dose 50
Molecular Docking Simulation
Molecular Dynamics Simulation
Mollusk Venoms
/ chemistry
Mutation
Oocytes
Recombinant Proteins
/ genetics
Shaker Superfamily of Potassium Channels
/ antagonists & inhibitors
Water
/ chemistry
Xenopus laevis
block
neurotoxin
pore modulation
potassium channels
structural water
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
pubmed:
25
8
2019
medline:
9
4
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Voltage-dependent potassium channels (K
Identifiants
pubmed: 31444298
pii: 1908903116
doi: 10.1073/pnas.1908903116
pmc: PMC6744907
doi:
Substances chimiques
Drosophila Proteins
0
Kv1.2 Potassium Channel
0
Mollusk Venoms
0
Recombinant Proteins
0
Sh protein, Drosophila
0
Shaker Superfamily of Potassium Channels
0
conkunitzin-S1, Conus striatus
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
18700-18709Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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