Orly Dym

Affiliations

Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

Publications (23)

Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.

The FEBS journal

Avec: Sarka Pokorna , Olga Khersonsky , Rosalie Lipsh-Sokolik , Adi Goldenzweig , Rebekka Nielsen , Yacov Ashani , Yoav Peleg , Tamar Unger , Shira Albeck , Orly Dym , Asa Tirosh , Rana Tarayra , Michaël Hocquemiller , Ralph Laufer , Shifra Ben-Dor , Israel Silman , Joel L Sussman , Sarel J Fleishman , Anthony H Futerman

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase.

Proceedings of the National Academy of Sciences of the United States of America

Avec: David Scheerer , Bharat V Adkar , Sanchari Bhattacharyya , Dorit Levy , Marija Iljina , Inbal Riven , Orly Dym , Gilad Haran , Eugene I Shakhnovich

Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.

The Journal of clinical investigation

Avec: Nathaniel L Gould , Gila R Scherer , Silvia Carvalho , Khriesto Shurrush , Haneen Kayyal , Efrat Edry , Alina Elkobi , Orit David , Maria Foqara , Darshit Thakar , Tommaso Pavesi , Vijendra Sharma , Matthew Walker , Matthew Maitland , Orly Dym , Shira Albeck , Yoav Peleg , Nicolas Germain , Ilana Babaev , Haleli Sharir , Maya Lalzar , Boris Shklyar , Neta Hazut , Mohammad Khamaisy , Maxime Lévesque , Gilles Lajoie , Massimo Avoli , Gabriel Amitai , Bruce Lefker , Chakrapani Subramanyam , Brian Shilton , Haim Barr , Kobi Rosenblum

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.

Nature microbiology

Avec: Jiří Zahradník , Shir Marciano , Maya Shemesh , Eyal Zoler , Daniel Harari , Jeanne Chiaravalli , Björn Meyer , Yinon Rudich , Chunlin Li , Ira Marton , Orly Dym , Nadav Elad , Mark G Lewis , Hanne Andersen , Matthew Gagne , Robert A Seder , Daniel C Douek , Gideon Schreiber

VWD domain stabilization by autocatalytic Asp-Pro cleavage.

Protein science : a publication of the Protein Society

Avec: Noa Yeshaya , Prashant Kumar Gupta , Orly Dym , David Morgenstern , Dan Thomas Major , Deborah Fass

PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE1A redox states alleviate photoinhibition during changes in light intensity.

Plant physiology

Avec: Amit Kumar Chaturvedi , Orly Dym , Yishai Levin , Robert Fluhr

Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.

PLoS computational biology

Avec: Shira Warszawski , Aliza Borenstein Katz , Rosalie Lipsh , Lev Khmelnitsky , Gili Ben Nissan , Gabriel Javitt , Orly Dym , Tamar Unger , Orli Knop , Shira Albeck , Ron Diskin , Deborah Fass , Michal Sharon , Sarel J Fleishman

The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.

Chemico-biological interactions

Avec: Dana A Novichkova , Sofya V Lushchekina , Orly Dym , Patrick Masson , Israel Silman , Joel L Sussman

Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.

Nature biotechnology

Avec: Hyla Allouche-Arnon , Olga Khersonsky , Nishanth D Tirukoti , Yoav Peleg , Orly Dym , Shira Albeck , Alexander Brandis , Tevie Mehlman , Liat Avram , Talia Harris , Nirbhay N Yadav , Sarel J Fleishman , Amnon Bar-Shir

gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution.

PloS one

Avec: Shahar Rezenman , Maor Knafo , Ivgeni Tsigalnitski , Shiri Barad , Ghil Jona , Dikla Levi , Orly Dym , Ziv Reich , Ruti Kapon

Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean.

ISME communications

Avec: Adva Shemi , Shifra Ben-Dor , Ron Rotkopf , Orly Dym , Assaf Vardi

Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.

Journal of molecular biology

Avec: Yoav Peleg , Renaud Vincentelli , Brett M Collins , Kai-En Chen , Emma K Livingstone , Saroja Weeratunga , Natalya Leneva , Qian Guo , Kim Remans , Kathryn Perez , Gro E K Bjerga , Øivind Larsen , Ondřej Vaněk , Ondřej Skořepa , Sophie Jacquemin , Arnaud Poterszman , Svend Kjær , Evangelos Christodoulou , Shira Albeck , Orly Dym , Elena Ainbinder , Tamar Unger , Anja Schuetz , Susann Matthes , Michael Bader , Ario de Marco , Paola Storici , Marta S Semrau , Peggy Stolt-Bergner , Christian Aigner , Sabine Suppmann , Adi Goldenzweig , Sarel J Fleishman

Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea.

The Journal of biological chemistry

Avec: Moshe Goldsmith , Shiri Barad , Maor Knafo , Alon Savidor , Shifra Ben-Dor , Alexander Brandis , Tevie Mehlman , Yoav Peleg , Shira Albeck , Orly Dym , Efrat Ben-Zeev , Ranjit S Barbole , Asaph Aharoni , Ziv Reich

The identification and characterization of an oxalyl-CoA synthetase from grass pea (

RSC chemical biology

Avec: Moshe Goldsmith , Shiri Barad , Yoav Peleg , Shira Albeck , Orly Dym , Alexander Brandis , Tevie Mehlman , Ziv Reich

Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.

Molecular biology and evolution

Avec: Moshe Ben-David , Misha Soskine , Artem Dubovetskyi , Kesava-Phaneendra Cherukuri , Orly Dym , Joel L Sussman , Qinghua Liao , Klaudia Szeler , Shina Caroline Lynn Kamerlin , Dan S Tawfik

Pore-modulating toxins exploit inherent slow inactivation to block K

Proceedings of the National Academy of Sciences of the United States of America

Avec: Izhar Karbat , Hagit Altman-Gueta , Shachar Fine , Tibor Szanto , Shelly Hamer-Rogotner , Orly Dym , Felix Frolow , Dalia Gordon , Gyorgy Panyi , Michael Gurevitz , Eitan Reuveny

A Molecular Lid Mechanism of K

Journal of molecular biology

Avec: Chandamita Saikia , Orly Dym , Hagit Altman-Gueta , Dalia Gordon , Eitan Reuveny , Izhar Karbat

Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.

PLoS computational biology

IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.

Acta crystallographica. Section D, Structural biology

Avec: Ed Daniel , Mirko M Maksimainen , Neil Smith , Ville Ratas , Ekaterina Biterova , Sudarshan N Murthy , M Tanvir Rahman , Tiila Riikka Kiema , Shruthi Sridhar , Gabriele Cordara , Subhadra Dalwani , Rajaram Venkatesan , Jaime Prilusky , Orly Dym , Lari Lehtiö , M Kristian Koski , Alun W Ashton , Joel L Sussman , Rik K Wierenga

Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill.

Cancers

Avec: Vishnu Mohan , Jean P Gaffney , Inna Solomonov , Maxim Levin , Mordehay Klepfish , Sophia Akbareian , Barbara Grünwald , Orly Dym , Miriam Eisenstein , Kenneth H Yu , David P Kelsen , Achim Krüger , Dylan R Edwards , Irit Sagi

Diversity of CysD domains in gel-forming mucins.

The FEBS journal

Avec: Lev Khmelnitsky , Ayala Milo , Orly Dym , Deborah Fass

The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.

Acta crystallographica. Section D, Structural biology

Avec: Orly Dym , Nidhi Aggarwal , Yacov Ashani , Haim Leader , Shira Albeck , Tamar Unger , Shelly Hamer-Rogotner , Israel Silman , Dan S Tawfik , Joel L Sussman

Stable Mammalian Serum Albumins Designed for Bacterial Expression.

Journal of molecular biology

Avec: Olga Khersonsky , Moshe Goldsmith , Irina Zaretsky , Shelly Hamer-Rogotner , Orly Dym , Tamar Unger , Meital Yona , Yael Fridmann-Sirkis , Sarel J Fleishman

Réseau de co-auteurs

Shira Albeck 9 collaborations

Yoav Peleg 6 collaborations

Tamar Unger 6 collaborations

Sarel J Fleishman 6 collaborations

Joel L Sussman 5 collaborations

Deborah Fass 4 collaborations

Olga Khersonsky 3 collaborations

Shifra Ben-Dor 3 collaborations

Israel Silman 3 collaborations

Lev Khmelnitsky 3 collaborations

Alexander Brandis 3 collaborations

Tevie Mehlman 3 collaborations

Shiri Barad 3 collaborations

Ziv Reich 3 collaborations

Moshe Goldsmith 3 collaborations

Shelly Hamer-Rogotner 3 collaborations

Adi Goldenzweig 2 collaborations

Yacov Ashani 2 collaborations

Shira Warszawski 2 collaborations

Aliza Borenstein Katz 2 collaborations

Rosalie Lipsh 2 collaborations

Gili Ben Nissan 2 collaborations

Gabriel Javitt 2 collaborations

Orli Knop 2 collaborations

Ron Diskin 2 collaborations

Michal Sharon 2 collaborations

Maor Knafo 2 collaborations

Dan S Tawfik 2 collaborations

Izhar Karbat 2 collaborations

Hagit Altman-Gueta 2 collaborations

Dalia Gordon 2 collaborations

Eitan Reuveny 2 collaborations

Sarka Pokorna 1 collaboration

Rosalie Lipsh-Sokolik 1 collaboration

Rebekka Nielsen 1 collaboration

Asa Tirosh 1 collaboration

Rana Tarayra 1 collaboration

Michaël Hocquemiller 1 collaboration

Ralph Laufer 1 collaboration

Anthony H Futerman 1 collaboration

David Scheerer 1 collaboration

Bharat V Adkar 1 collaboration

Sanchari Bhattacharyya 1 collaboration

Dorit Levy 1 collaboration

Marija Iljina 1 collaboration

Inbal Riven 1 collaboration

Gilad Haran 1 collaboration

Eugene I Shakhnovich 1 collaboration

Nathaniel L Gould 1 collaboration

Gila R Scherer 1 collaboration

Silvia Carvalho 1 collaboration

Khriesto Shurrush 1 collaboration

Haneen Kayyal 1 collaboration

Efrat Edry 1 collaboration

Alina Elkobi 1 collaboration

Orit David 1 collaboration

Maria Foqara 1 collaboration

Darshit Thakar 1 collaboration

Tommaso Pavesi 1 collaboration

Vijendra Sharma 1 collaboration

Matthew Walker 1 collaboration

Matthew Maitland 1 collaboration

Nicolas Germain 1 collaboration

Ilana Babaev 1 collaboration

Haleli Sharir 1 collaboration

Maya Lalzar 1 collaboration

Boris Shklyar 1 collaboration

Neta Hazut 1 collaboration

Mohammad Khamaisy 1 collaboration

Maxime Lévesque 1 collaboration

Gilles Lajoie 1 collaboration

Massimo Avoli 1 collaboration

Gabriel Amitai 1 collaboration

Bruce Lefker 1 collaboration

Chakrapani Subramanyam 1 collaboration

Brian Shilton 1 collaboration

Haim Barr 1 collaboration

Kobi Rosenblum 1 collaboration

Jiří Zahradník 1 collaboration

Shir Marciano 1 collaboration

Maya Shemesh 1 collaboration

Eyal Zoler 1 collaboration

Daniel Harari 1 collaboration

Jeanne Chiaravalli 1 collaboration

Björn Meyer 1 collaboration

Yinon Rudich 1 collaboration

Chunlin Li 1 collaboration

Ira Marton 1 collaboration

Nadav Elad 1 collaboration

Mark G Lewis 1 collaboration

Hanne Andersen 1 collaboration

Matthew Gagne 1 collaboration

Robert A Seder 1 collaboration

Daniel C Douek 1 collaboration

Gideon Schreiber 1 collaboration

Noa Yeshaya 1 collaboration

Prashant Kumar Gupta 1 collaboration

David Morgenstern 1 collaboration

Dan Thomas Major 1 collaboration

Amit Kumar Chaturvedi 1 collaboration

Yishai Levin 1 collaboration

Robert Fluhr 1 collaboration

Dana A Novichkova 1 collaboration

Sofya V Lushchekina 1 collaboration

Patrick Masson 1 collaboration

Hyla Allouche-Arnon 1 collaboration

Nishanth D Tirukoti 1 collaboration

Liat Avram 1 collaboration

Talia Harris 1 collaboration

Nirbhay N Yadav 1 collaboration

Amnon Bar-Shir 1 collaboration

Shahar Rezenman 1 collaboration

Ivgeni Tsigalnitski 1 collaboration

Ghil Jona 1 collaboration

Dikla Levi 1 collaboration

Ruti Kapon 1 collaboration

Adva Shemi 1 collaboration

Ron Rotkopf 1 collaboration

Assaf Vardi 1 collaboration

Renaud Vincentelli 1 collaboration

Brett M Collins 1 collaboration

Kai-En Chen 1 collaboration

Emma K Livingstone 1 collaboration

Saroja Weeratunga 1 collaboration

Natalya Leneva 1 collaboration

Qian Guo 1 collaboration

Kim Remans 1 collaboration

Kathryn Perez 1 collaboration

Gro E K Bjerga 1 collaboration

Øivind Larsen 1 collaboration

Ondřej Vaněk 1 collaboration

Ondřej Skořepa 1 collaboration

Sophie Jacquemin 1 collaboration

Arnaud Poterszman 1 collaboration

Svend Kjær 1 collaboration

Evangelos Christodoulou 1 collaboration

Elena Ainbinder 1 collaboration

Anja Schuetz 1 collaboration

Susann Matthes 1 collaboration

Michael Bader 1 collaboration

Ario de Marco 1 collaboration

Paola Storici 1 collaboration

Marta S Semrau 1 collaboration

Peggy Stolt-Bergner 1 collaboration

Christian Aigner 1 collaboration

Sabine Suppmann 1 collaboration

Alon Savidor 1 collaboration

Efrat Ben-Zeev 1 collaboration

Ranjit S Barbole 1 collaboration

Asaph Aharoni 1 collaboration

Moshe Ben-David 1 collaboration

Misha Soskine 1 collaboration

Artem Dubovetskyi 1 collaboration

Kesava-Phaneendra Cherukuri 1 collaboration

Qinghua Liao 1 collaboration

Klaudia Szeler 1 collaboration

Shina Caroline Lynn Kamerlin 1 collaboration

Shachar Fine 1 collaboration

Tibor Szanto 1 collaboration

Felix Frolow 1 collaboration

Gyorgy Panyi 1 collaboration

Michael Gurevitz 1 collaboration

Chandamita Saikia 1 collaboration

Ed Daniel 1 collaboration

Mirko M Maksimainen 1 collaboration

Neil Smith 1 collaboration

Ville Ratas 1 collaboration

Ekaterina Biterova 1 collaboration

Sudarshan N Murthy 1 collaboration

M Tanvir Rahman 1 collaboration

Tiila Riikka Kiema 1 collaboration

Shruthi Sridhar 1 collaboration

Gabriele Cordara 1 collaboration

Subhadra Dalwani 1 collaboration

Rajaram Venkatesan 1 collaboration

Jaime Prilusky 1 collaboration

Lari Lehtiö 1 collaboration

M Kristian Koski 1 collaboration

Alun W Ashton 1 collaboration

Rik K Wierenga 1 collaboration

Vishnu Mohan 1 collaboration

Jean P Gaffney 1 collaboration

Inna Solomonov 1 collaboration

Maxim Levin 1 collaboration

Mordehay Klepfish 1 collaboration

Sophia Akbareian 1 collaboration

Barbara Grünwald 1 collaboration

Miriam Eisenstein 1 collaboration

Kenneth H Yu 1 collaboration

David P Kelsen 1 collaboration

Achim Krüger 1 collaboration

Dylan R Edwards 1 collaboration

Irit Sagi 1 collaboration

Ayala Milo 1 collaboration

Nidhi Aggarwal 1 collaboration

Haim Leader 1 collaboration

Irina Zaretsky 1 collaboration

Meital Yona 1 collaboration

Yael Fridmann-Sirkis 1 collaboration