TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia.
Animals
Capillary Permeability
/ physiology
Cell Line
Endothelium, Vascular
/ metabolism
Endotoxemia
/ metabolism
Human Umbilical Vein Endothelial Cells
Humans
Kidney
/ metabolism
Kidney Diseases
/ metabolism
Male
Protein Serine-Threonine Kinases
/ genetics
Rats
Rats, Sprague-Dawley
Signal Transduction
/ physiology
TRPM Cation Channels
/ genetics
Journal
Laboratory investigation; a journal of technical methods and pathology
ISSN: 1530-0307
Titre abrégé: Lab Invest
Pays: United States
ID NLM: 0376617
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
15
01
2019
accepted:
19
07
2019
revised:
24
06
2019
pubmed:
25
8
2019
medline:
25
9
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Sepsis is the main cause of mortality in patients admitted to intensive care units. During sepsis, endothelial permeability is severely augmented, contributing to renal dysfunction and patient mortality. Ca
Identifiants
pubmed: 31444399
doi: 10.1038/s41374-019-0304-z
pii: S0023-6837(22)01278-8
doi:
Substances chimiques
TRPM Cation Channels
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
TRPM7 protein, human
EC 2.7.11.1
Trpm7 protein, rat
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-249Références
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