Sodium-activated potassium channels moderate excitability in vascular smooth muscle.

Angiotensin II Animals Intermediate-Conductance Calcium-Activated Potassium Channels / genetics Mice Mice, Knockout Muscle, Smooth, Vascular / physiology Potassium Channels, Sodium-Activated / genetics Rats Rats, Sprague-Dawley
KNa1.1 KNa1.2 Slo1 Slo2.1 angiotensin II persistent sodium current potassium channel vascular smooth muscle

Journal

The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262

Informations de publication

Date de publication:
10 2019
Historique:
received: 18 07 2019
accepted: 19 08 2019
pubmed: 25 8 2019
medline: 29 7 2020
entrez: 25 8 2019
Statut: ppublish

Résumé

We report that a sodium-activated potassium current, IK Although several potassium currents have been reported to play a role in arterial smooth muscle (ASM), we find that one of the largest contributors to membrane conductance in both conduit and resistance ASMs has been inadvertently overlooked. In the present study, we show that IK

Identifiants

DOI: 10.1113/JP278279 PMID: 31444905 PMC: PMC6800802
pubmed: 31444905
doi: 10.1113/JP278279
pmc: PMC6800802
mid: NIHMS1047943
doi:

Substances chimiques

Intermediate-Conductance Calcium-Activated Potassium Channels 0
Potassium Channels, Sodium-Activated 0
Angiotensin II 11128-99-7

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5093-5108

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM114694
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL135400
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD088097
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM067154
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH107955
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS061871
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS088611
Pays : United States

Informations de copyright

© 2019 The Authors. The Journal of Physiology © 2019 The Physiological Society.

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Auteurs

Ping Li (P)

Department of Neuroscience.

Carmen M Halabi (CM)

Department of Pediatrics.
ORCID: 0000-0003-4889-8131

Richard Stewart (R)

Department of Neuroscience.

Alice Butler (A)

Department of Neuroscience.

Bobbie Brown (B)

Department of Neuroscience.

Xiaoming Xia (X)

Department of Anesthesiology.

Celia Santi (C)

Department of Neuroscience.
Department of Obstetrics and Gynecology.
ORCID: 0000-0002-5101-1303

Sarah England (S)

Department of Obstetrics and Gynecology.

Juan Ferreira (J)

Department of Neuroscience.
Department of Obstetrics and Gynecology.

Robert P Mecham (RP)

Department of Cell Biology and Physiology.

Lawrence Salkoff (L)

Department of Neuroscience.
Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
ORCID: 0000-0001-7400-6550

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Angiotensine-II › Sodium-activated potassium channels moderate...
questionsmedicales.fr › Eucaryotes › Animaux › Sodium-activated potassium channels moderate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de conductance intermédiaire › Sodium-activated potassium channels moderate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sodium-activated potassium channels moderate...
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questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › Sodium-activated potassium channels moderate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques activés par le sodium › Sodium-activated potassium channels moderate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Sodium-activated potassium channels moderate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Sodium-activated potassium channels moderate...