Age and pain differences in non-verbal fluency performance: Associations with cortical thickness and subcortical volumes.
Adolescent
Adult
Aged
Aged, 80 and over
Aging
/ pathology
Cerebral Cortex
/ diagnostic imaging
Chronic Pain
/ diagnostic imaging
Cognition
/ physiology
Executive Function
/ physiology
Female
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Neuropsychological Tests
Pain Measurement
/ methods
Pain Threshold
/ physiology
Self Report
Sensory Thresholds
/ physiology
Young Adult
Age
Brain structure
Cognition
Executive function
Fluency
Gray matter
Pain
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
26
11
2018
revised:
18
08
2019
accepted:
19
08
2019
pubmed:
25
8
2019
medline:
14
7
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Musculoskeletal pain is a cause of disability in older individuals and is commonly associated with executive function deficits. In particular, verbal fluency deficits have been previously reported in older individuals with and without musculoskeletal pain, however, no studies have examined non-verbal fluency. The present study investigated non-verbal fluency performance in younger and older individuals and associations with clinical and experimental pain. The NEPAL study included older (n = 63) and younger (n = 28) individuals who completed demographic, and clinical pain assessments followed by a multi-modal QST battery. A subset of participants (older n = 39/63, younger n = 11/28) underwent a structural 3T MRI to extract cortical thickness and subcortical gray matter volumes. The Ruff Figural Fluency Test was administered to assess fluid/divergent thinking, ability to shift cognitive set, and planning strategies. Total Unique Designs drawn and Error Ratio assessed participants' ability to minimize repetition while maximizing unique productions. Adjusting for race and education, older participants with chronic pain had significantly lower Total Unique Designs (67.1 ± 20.3) compared to older adults without chronic pain (78.8 ± 15.9) and younger controls (93.8 ± 20.3, p < 0.001). Within the older sample, those with chronic pain had a significantly greater Error Ratio (0.22 ± 0.3) compared to those without chronic pain (0.09 ± 0.06) and younger controls (0.05 ± 0.05, p = 0.002). In older participants, greater Total Unique Design scores were significantly associated only with lower pressure pain sensitivity (r = 0.300, p = 0.031) while greater Error Ratio scores were significantly associated with greater thermal pain sensitivity (r = 0.304, p = 0.027). However, after accounting for sleep quality, clinical and experimental pain associations were eliminated. Across all participants, non-verbal fluency performance was associated with cortical thickness in frontal, parietal and temporal regions as well as several subcortical gray matter structures even after adjusting for multiple comparisons (p's < 0.001). Our findings suggest a pain-related deficit in non-verbal fluency beyond the established age-related decrements that may be dependent on sleep quality and was associated with specific patterns of gray matter structure.
Identifiants
pubmed: 31445107
pii: S0531-5565(18)30725-3
doi: 10.1016/j.exger.2019.110708
pmc: PMC6760861
mid: NIHMS1538445
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
110708Subventions
Organisme : NIA NIH HHS
ID : K01 AG048259
Pays : United States
Organisme : NIA NIH HHS
ID : L30 AG043172
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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