Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood.

Adult Bipolar Disorder / genetics Child Cognition Cognitive Dysfunction Executive Function Female Humans Longitudinal Studies Male Multifactorial Inheritance Polymorphism, Single Nucleotide Risk Factors Schizophrenia / diagnosis

ALSPAC Bipolar disorder Cognition Genetics Polygenic risk score

Journal

Journal of affective disorders

ISSN: 1573-2517

Titre abrégé: J Affect Disord

Pays: Netherlands

ID NLM: 7906073

Informations de publication

Date de publication:
01 12 2019

Historique:

received: 18 01 2019

revised: 01 07 2019

accepted: 17 08 2019

pubmed: 25 8 2019

medline: 21 7 2020

entrez: 25 8 2019

Statut: ppublish

Résumé

Identifying phenotypic manifestations of genetic risk for bipolar disorder (BD) in childhood could increase our understanding of aetiological mechanisms. To examine whether BD genetic risk is associated with childhood (age 8 years) cognitive function. Using data from the Avon Longitudinal Study of Parents and Children, we examined associations between polygenic risk scores for BD (BD-PRS) derived using Psychiatric Genomics Consortium summary data at p-thresholds (P At P The BD-PRS still explains only a small proportion of the variance for BD which will have reduced power to detect associations. Genetic risk for BD manifests as impaired cognition in childhood, and this is driven by risk SNPs that are also shared with SZ genetic risk. Further elucidation of which cognitive domains are most affected by genetic risk for BD could help understanding of aetiology and improve prediction of BD.

Identifiants

DOI: 10.1016/j.jad.2019.08.040 PMID: 31445336

pubmed: 31445336

pii: S0165-0327(19)30129-6

doi: 10.1016/j.jad.2019.08.040

pii:

doi:

Types de publication

Journal Article

Langues

eng