Pathogenesis and management of fracture-related infection.
Antimicrobial therapy
Consensus guidelines
Diagnosis
Diagnostic criteria
Fracture
Fracture-related infection
Infection
Treatment
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
23
05
2019
revised:
09
08
2019
accepted:
10
08
2019
pubmed:
26
8
2019
medline:
5
1
2021
entrez:
26
8
2019
Statut:
ppublish
Résumé
Both fracture-related infections (FRIs) and periprosthetic joint infections (PJIs) include orthopaedic implant-associated infections. However, key aspects of management differ due to the bone and soft tissue damage in FRIs and the option of removing the implant after fracture healing. In contrast to PJIs, research and guidelines for diagnosis and treatment in FRIs are scarce. This narrative review aims to update clinical microbiologists, infectious disease specialists and surgeons on the management of FRIs. A computerized search of PubMed was performed to identify relevant studies. Search terms included 'Fracture' and 'Infection'. The reference lists of all retrieved articles were checked for additional relevant references. In addition, when scientific evidence was lacking, recommendations are based on expert opinion. Pathogenesis, prevention, diagnosis and treatment of FRIs are presented. Whenever available, specific data of patients with FRI are discussed. Management of patients with FRI should take into account FRI-specific features. Treatment pathways should implement a multidisciplinary approach to achieve a good outcome. Recently, international consensus guidelines were developed to improve the quality of care for patients suffering from this severe complication, which are highlighted in this review.
Sections du résumé
BACKGROUND
BACKGROUND
Both fracture-related infections (FRIs) and periprosthetic joint infections (PJIs) include orthopaedic implant-associated infections. However, key aspects of management differ due to the bone and soft tissue damage in FRIs and the option of removing the implant after fracture healing. In contrast to PJIs, research and guidelines for diagnosis and treatment in FRIs are scarce.
OBJECTIVES
OBJECTIVE
This narrative review aims to update clinical microbiologists, infectious disease specialists and surgeons on the management of FRIs.
SOURCES
METHODS
A computerized search of PubMed was performed to identify relevant studies. Search terms included 'Fracture' and 'Infection'. The reference lists of all retrieved articles were checked for additional relevant references. In addition, when scientific evidence was lacking, recommendations are based on expert opinion.
CONTENT
BACKGROUND
Pathogenesis, prevention, diagnosis and treatment of FRIs are presented. Whenever available, specific data of patients with FRI are discussed.
IMPLICATIONS
CONCLUSIONS
Management of patients with FRI should take into account FRI-specific features. Treatment pathways should implement a multidisciplinary approach to achieve a good outcome. Recently, international consensus guidelines were developed to improve the quality of care for patients suffering from this severe complication, which are highlighted in this review.
Identifiants
pubmed: 31446152
pii: S1198-743X(19)30447-1
doi: 10.1016/j.cmi.2019.08.006
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
572-578Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.