Glioprotective Effect of Chitosan-Coated Rosmarinic Acid Nanoemulsions Against Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Rat Astrocyte Primary Cultures.
Animals
Animals, Newborn
Anti-Inflammatory Agents
/ pharmacology
Antioxidants
/ pharmacology
Astrocytes
/ drug effects
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cells, Cultured
Chitosan
/ chemistry
Cinnamates
/ chemistry
Depsides
/ chemistry
Emulsions
Glial Fibrillary Acidic Protein
/ metabolism
Inflammation
/ pathology
Lipopolysaccharides
Nanoparticles
/ chemistry
Neuroglia
/ drug effects
Neuroprotective Agents
/ chemistry
Oxidative Stress
/ drug effects
Rats, Wistar
Rosmarinic Acid
Astrocytes
Chitosan-coated nanoemulsions
Glioprotective effect
Lipopolysaccharide
Rosmarinic acid
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
23
04
2019
accepted:
12
08
2019
pubmed:
26
8
2019
medline:
21
10
2020
entrez:
26
8
2019
Statut:
ppublish
Résumé
Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new potential neuroprotective therapy. In this sense, the present study aimed to evaluate the protective and/or therapeutic potential of RA CNE in inflammation/oxidative stress induced by LPS (1 μg mL
Identifiants
pubmed: 31446560
doi: 10.1007/s10571-019-00727-y
pii: 10.1007/s10571-019-00727-y
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Cinnamates
0
Depsides
0
Emulsions
0
Glial Fibrillary Acidic Protein
0
Lipopolysaccharides
0
Neuroprotective Agents
0
Chitosan
9012-76-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-139Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 459619/2014-4
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 310846/2014-5
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 422298/2016-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 142202/2018-5
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 16/2551-0000265-7
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 16/2551-0000473-0
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 17/2551-0001273-9
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil
ID : Finance Code 001
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