Ribosomal DNA and the Nucleolus as Keystones of Nuclear Architecture, Organization, and Function.
Hi-C
NADs
chromatin territories
chromosome territories
nuclear organization
rDNA contacts
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
16
06
2019
revised:
23
07
2019
accepted:
25
07
2019
pubmed:
27
8
2019
medline:
1
7
2020
entrez:
27
8
2019
Statut:
ppublish
Résumé
The multicopy ribosomal DNA (rDNA) array gives origin to the nucleolus, a large nonmembrane-bound organelle that occupies a substantial volume within the cell nucleus. The rDNA/nucleolus has emerged as a coordinating hub in which seemingly disparate cellular functions converge, and from which a variety of cellular and organismal phenotypes emerge. However, the role of the nucleolus as a determinant and organizer of nuclear architecture and other epigenetic states of the genome is not well understood. We discuss the role of rDNA and the nucleolus in nuclear organization and function - from nucleolus-associated domains (NADs) to the regulation of imprinted loci and X chromosome inactivation, as well as rDNA contact maps that anchor and position the rDNA relative to the rest of the genome. The influence of the nucleolus on nuclear organization undoubtedly modulates diverse biological processes from metabolism to cell proliferation, genome-wide gene expression, maintenance of epigenetic states, and aging.
Identifiants
pubmed: 31447250
pii: S0168-9525(19)30160-X
doi: 10.1016/j.tig.2019.07.011
pmc: PMC8487316
mid: NIHMS1741614
pii:
doi:
Substances chimiques
DNA, Ribosomal
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
710-723Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES027981
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM122088
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Références
Mutat Res. 2004 Feb 14;557(2):151-8
pubmed: 14729369
Biochim Biophys Acta. 2014 Jun;1842(6):860-8
pubmed: 24389328
Nat Neurosci. 2007 Apr;10(4):427-35
pubmed: 17334360
Nucleic Acids Res. 2011 Jul;39(12):4949-60
pubmed: 21355038
Genome Res. 2019 Mar;29(3):325-333
pubmed: 30765617
Cell. 2008 Feb 8;132(3):422-33
pubmed: 18237772
Curr Opin Cell Biol. 2018 Jun;52:105-111
pubmed: 29529563
Genome Biol Evol. 2016 Dec 31;8(11):3545-3558
pubmed: 27797956
Mol Cell. 2004 Jan 30;13(2):291-8
pubmed: 14759373
Bioessays. 2008 Mar;30(3):267-72
pubmed: 18293366
Nat Commun. 2014 Sep 11;5:4850
pubmed: 25209200
Oncogene. 2000 Oct 12;19(43):4988-99
pubmed: 11042686
Science. 2009 Oct 9;326(5950):289-93
pubmed: 19815776
Curr Opin Cell Biol. 2017 Jun;46:81-86
pubmed: 28431265
Histochem Cell Biol. 2018 Sep;150(3):209-225
pubmed: 30046888
Cell. 2009 Jun 26;137(7):1194-211
pubmed: 19563753
Hum Genet. 1976 Dec 29;35(1):27-34
pubmed: 1002162
Curr Biol. 2002 Jan 8;12(1):1-11
pubmed: 11790298
J Immunol. 2017 Dec 15;199(12):3981-3990
pubmed: 29070672
PLoS Biol. 2010 Oct 26;8(10):e1000522
pubmed: 21048991
J Neurosci. 2008 Nov 26;28(48):12759-64
pubmed: 19036968
Genes Dev. 2011 Jun 15;25(12):1289-305
pubmed: 21685364
Yeast. 2009 Feb;26(2):125-38
pubmed: 19235779
Trends Neurosci. 2012 May;35(5):305-14
pubmed: 22305768
Science. 1984 Jun 8;224(4653):1121-4
pubmed: 6719137
Chromosoma. 2011 Oct;120(5):481-99
pubmed: 21698343
Exp Cell Res. 1992 Jan;198(1):135-43
pubmed: 1727047
J Cell Biol. 1999 Dec 27;147(7):1409-18
pubmed: 10613900
J Cell Sci. 1992 Apr;101 ( Pt 4):751-7
pubmed: 1527177
Nature. 2007 Jun 7;447(7145):730-4
pubmed: 17554310
Cell. 2018 Jul 26;174(3):744-757.e24
pubmed: 29887377
PLoS Genet. 2011 Apr;7(4):e1001376
pubmed: 21533076
Exp Cell Res. 1986 Nov;167(1):227-40
pubmed: 3758203
Nature. 2010 Sep 23;467(7314):430-5
pubmed: 20720539
Cell Rep. 2016 Mar 22;14(11):2519-27
pubmed: 26972008
Oncogene. 2009 Apr 23;28(16):1833-42
pubmed: 19270725
Heredity (Edinb). 2013 Jul;111(1):23-33
pubmed: 23512008
Epigenetics Chromatin. 2010 Nov 08;3(1):19
pubmed: 21059229
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8161-6
pubmed: 22570494
J Biol Chem. 2013 Sep 6;288(36):26067-26077
pubmed: 23884423
J Vis Exp. 2010 May 06;(39):
pubmed: 20461051
Genome Res. 2007 Aug;17(8):1146-60
pubmed: 17623812
Nucleic Acids Res. 2007;35(7):2191-8
pubmed: 17355984
J Struct Biol. 1995 Jan-Feb;114(1):1-22
pubmed: 7772414
PLoS Genet. 2017 Sep 7;13(9):e1006994
pubmed: 28880866
Science. 2003 Nov 21;302(5649):1399-401
pubmed: 14631041
Nucleus. 2014;5(6):626-35
pubmed: 25493640
Nat Commun. 2017 Aug 30;8(1):328
pubmed: 28855503
Nucleic Acids Res. 2014 May;42(9):5505-17
pubmed: 24609384
Genes Dev. 2016 Jul 15;30(14):1598-610
pubmed: 27474438
J Cell Sci. 1994 Feb;107 ( Pt 2):639-48
pubmed: 8207086
J Cell Biol. 1991 May;113(4):715-29
pubmed: 2026646
Exp Cell Res. 1992 Jun;200(2):339-50
pubmed: 1572401
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1431-5
pubmed: 6369327
Nat Genet. 2002 Nov;32(3):393-6
pubmed: 12368916
Commun Biol. 2019 Jan 28;2:39
pubmed: 30701204
Mol Cell. 2015 Nov 19;60(4):676-84
pubmed: 26527277
Biol Psychiatry. 2019 Jul 15;86(2):87-96
pubmed: 30846302
Genes Dev. 2005 Jan 1;19(1):50-64
pubmed: 15598984
Hum Mol Genet. 2005 Jul 15;14(14):2035-43
pubmed: 15930015
Nature. 2008 Jun 12;453(7197):948-51
pubmed: 18463634
Nucleus. 2019 Dec;10(1):67-72
pubmed: 30870088
Mol Biol Cell. 2010 Nov 1;21(21):3735-48
pubmed: 20826608
Gynecol Oncol. 1990 Sep;38(3):340-2
pubmed: 2227545
Mol Cell Biol. 2017 Nov 28;37(24):
pubmed: 28993479
Eur J Cell Biol. 1989 Oct;50(1):235-43
pubmed: 2612500
Front Genet. 2015 Feb 16;6:22
pubmed: 25763008
Genes Dev. 2008 Dec 15;22(24):3409-21
pubmed: 19141474
Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13403-8
pubmed: 16938878
PLoS Genet. 2017 Jul 17;13(7):e1006899
pubmed: 28715449
Cell. 2007 May 18;129(4):693-706
pubmed: 17512404
Neurology. 2009 Sep 1;73(9):665-73
pubmed: 19587326
G3 (Bethesda). 2012 Dec;2(12):1521-8
pubmed: 23275875
Chromosoma. 1988;96(6):397-410
pubmed: 3219911
Oncogene. 2018 May;37(18):2351-2366
pubmed: 29429989
Mol Biol Cell. 2000 Aug;11(8):2705-17
pubmed: 10930464
Mol Cell Biol. 2004 Oct;24(20):9048-58
pubmed: 15456878
Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1679-84
pubmed: 11431428
Genes Dev. 1998 Aug 15;12(16):2463-8
pubmed: 9716399
Cell Death Differ. 2011 Nov;18(11):1726-35
pubmed: 21546905
J Cell Biol. 2001 Apr 2;153(1):169-76
pubmed: 11285283
Genome Res. 2013 Dec;23(12):2003-12
pubmed: 23990606
PLoS Genet. 2010 Mar 26;6(3):e1000889
pubmed: 20361057
Genes Dev. 2010 Oct 15;24(20):2264-9
pubmed: 20952535
Cancer Cell. 2011 Jun 14;19(6):765-75
pubmed: 21665150
Genes Dev. 2014 Feb 1;28(3):220-30
pubmed: 24449107
Nat Commun. 2016 Aug 30;8:16083
pubmed: 28853436
Trends Genet. 2011 Apr;27(4):149-56
pubmed: 21295884
Nat Cell Biol. 2006 May;8(5):458-69
pubmed: 16622419
Surg Neurol. 1999 May;51(5):536-42
pubmed: 10321885
PLoS Genet. 2017 Jun 22;13(6):e1006771
pubmed: 28640831
J Cell Biol. 2002 May 27;157(5):743-8
pubmed: 12034768
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2485-90
pubmed: 25583482
Cancer Lett. 1997 Jan 1;111(1-2):127-31
pubmed: 9022137
Nat Med. 2008 Feb;14(2):125-33
pubmed: 18246078
Cell Rep. 2016 Aug 9;16(6):1574-1587
pubmed: 27477271
Nat Cell Biol. 2005 Mar;7(3):303-10
pubmed: 15723053
Cell Rep. 2015 Oct 13;13(2):251-9
pubmed: 26440899
J Struct Biol. 2007 Oct;160(1):49-56
pubmed: 17698369
Nucleus. 2016 Apr 25;7(2):203-15
pubmed: 26934002
Science. 2010 Feb 5;327(5966):693-6
pubmed: 20133573
Cell. 2017 May 18;169(5):780-791
pubmed: 28525751
Mol Cell Biol. 2017 Oct 27;37(22):
pubmed: 28874518
Nat Commun. 2016 Jan 05;7:10174
pubmed: 26729372
Mol Cell Biol. 2008 Jun;28(11):3713-28
pubmed: 18299392
Science. 2000 May 26;288(5470):1385-9
pubmed: 10827942
Genes Dev. 2005 May 15;19(10):1199-210
pubmed: 15905408
Mol Cell Biol. 1991 Aug;11(8):3842-9
pubmed: 1712897
Mol Biol Cell. 2005 May;16(5):2395-413
pubmed: 15758027
Biochim Biophys Acta. 2014 Jun;1842(6):765-8
pubmed: 24412987
EMBO J. 2001 Mar 15;20(6):1383-93
pubmed: 11250904
PLoS Genet. 2018 Mar 23;14(3):e1007258
pubmed: 29570716
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21081-6
pubmed: 23204437
Biol Cell. 1985;54(2):123-33
pubmed: 2933102
Genes Dev. 1988 Dec;2(12B):1745-63
pubmed: 3149250
Trends Biochem Sci. 1999 Nov;24(11):437-40
pubmed: 10542411
PLoS One. 2017 Jun 2;12(6):e0178821
pubmed: 28575119
PLoS One. 2011;6(7):e22585
pubmed: 21799908
Cell Mol Life Sci. 2017 Aug;74(16):3057-3064
pubmed: 28391361
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9882-7
pubmed: 27535936
Mol Cell Biol. 2000 Aug;20(16):5930-8
pubmed: 10913176
Nucleus. 2013 Nov-Dec;4(6):478-86
pubmed: 24513678
Anticancer Res. 2003 Mar-Apr;23(2B):1489-93
pubmed: 12820414
Mol Biol Cell. 2005 Jan;16(1):260-9
pubmed: 15496452
J Biol Chem. 2014 Dec 12;289(50):34601-19
pubmed: 25349213
Nat Cell Biol. 2005 Mar;7(3):311-8
pubmed: 15723054
J Biol Chem. 2005 Mar 11;280(10):8637-9
pubmed: 15654076
PLoS One. 2017 Nov 30;12(11):e0187977
pubmed: 29190286
Nature. 2005 Jan 6;433(7021):77-83
pubmed: 15635413