Genomic determinants of speciation and spread of the
Bacterial Proteins
/ genetics
Datasets as Topic
Gene Expression
Genetic Loci
Genetic Speciation
Genome, Bacterial
History, 21st Century
History, Ancient
Host-Pathogen Interactions
/ genetics
Humans
Mutation
Mycobacterium
/ classification
Mycobacterium tuberculosis
/ classification
Phylogeny
Recombination, Genetic
Selection, Genetic
Tuberculosis
/ epidemiology
Virulence
Virulence Factors
/ genetics
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
10
12
2018
accepted:
10
05
2019
entrez:
27
8
2019
pubmed:
27
8
2019
medline:
2
5
2020
Statut:
epublish
Résumé
Models on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population genomics events leading to the emergence of the tuberculosis pathogen. The emergence is characterized by a combination of recombination events involving core pathogenesis functions and purifying selection on early diverging loci. We identify the
Identifiants
pubmed: 31448322
doi: 10.1126/sciadv.aaw3307
pii: aaw3307
pmc: PMC6691555
doi:
Substances chimiques
Bacterial Proteins
0
Virulence Factors
0
PhoR protein, Bacteria
107121-16-4
Types de publication
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaw3307Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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