Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR-2 inhibitors.

Antineoplastic Agents / chemical synthesis Benzoxazoles / chemical synthesis Cell Proliferation / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Drug Design HCT116 Cells Hep G2 Cells Humans Inhibitory Concentration 50 MCF-7 Cells Molecular Docking Simulation Molecular Structure Protein Binding Structure-Activity Relationship Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
VEGFR-2 inhibitors anticancer agents benzoxazole molecular docking

Journal

Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 13 04 2019
revised: 12 07 2019
accepted: 17 07 2019
pubmed: 27 8 2019
medline: 19 2 2020
entrez: 27 8 2019
Statut: ppublish

Résumé

Novel series of benzoxazoles 4

Identifiants

DOI: 10.1002/ardp.201900113 PMID: 31448458
pubmed: 31448458
doi: 10.1002/ardp.201900113
doi:

Substances chimiques

Antineoplastic Agents 0
Benzoxazoles 0
KDR protein, human EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2 EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1900113

Informations de copyright

© 2019 Deutsche Pharmazeutische Gesellschaft.

Auteurs

Abdel-Ghany A El-Helby (AA)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Helmy Sakr (H)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Ibrahim H Eissa (IH)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Hamada Abulkhair (H)

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Ahmed A Al-Karmalawy (AA)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Khaled El-Adl (K)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Drug Technology, Heliopolis University for Sustainable Development, Cairo, Egypt.
ORCID: 0000-0002-8922-9770

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzoxazoles › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules HCT116 › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, synthesis, molecular docking, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › Récepteur-2 au facteur croissance endothéliale vasculaire › Design, synthesis, molecular docking, and...