Outdoor fungal spores and acute respiratory effects in vulnerable individuals.

Acute Disease / epidemiology Air Microbiology Asthma Breath Tests Cohort Studies Cross-Sectional Studies Exhalation Humans Inhalation Exposure / statistics & numerical data Nitric Oxide Respiratory Tract Diseases / epidemiology Spores, Fungal Vulnerable Populations / statistics & numerical data
Airway inflammation Asthma Lung function fungi sensitization

Journal

Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621

Informations de publication

Date de publication:
11 2019
Historique:
received: 08 05 2019
revised: 01 08 2019
accepted: 15 08 2019
pubmed: 27 8 2019
medline: 25 4 2020
entrez: 27 8 2019
Statut: ppublish

Résumé

Many outdoor fungal spores are ubiquitous, respirable and possibly allergenic. They may contribute to asthma symptoms; however, little is known about their effects on respiratory function. To investigate if outdoor fungal spore levels were associated with lung function or airway inflammation, and whether fungal sensitization or current asthma modified any associations. Cross-sectional associations between same day (Lag0) and cumulative 3-day lagged (Lag0-3) counts of 12 outdoor fungal spore taxa and pre-bronchodilator spirometry (FEV Mixed associations were found. Higher levels of Ustilago/smuts were associated with lower lung function at Lag0 (FEV Exposure to outdoor fungal spores may be associated with lower lung function and increased airway inflammation, particularly in those with fungal sensitization and/or current asthma.

Sections du résumé

BACKGROUND
Many outdoor fungal spores are ubiquitous, respirable and possibly allergenic. They may contribute to asthma symptoms; however, little is known about their effects on respiratory function.
OBJECTIVE
To investigate if outdoor fungal spore levels were associated with lung function or airway inflammation, and whether fungal sensitization or current asthma modified any associations.
METHODS
Cross-sectional associations between same day (Lag0) and cumulative 3-day lagged (Lag0-3) counts of 12 outdoor fungal spore taxa and pre-bronchodilator spirometry (FEV
RESULTS
Mixed associations were found. Higher levels of Ustilago/smuts were associated with lower lung function at Lag0 (FEV
CONCLUSION
Exposure to outdoor fungal spores may be associated with lower lung function and increased airway inflammation, particularly in those with fungal sensitization and/or current asthma.

Identifiants

DOI: 10.1016/j.envres.2019.108675 PMID: 31450143
pubmed: 31450143
pii: S0013-9351(19)30472-4
doi: 10.1016/j.envres.2019.108675
pii:
doi:

Substances chimiques

Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108675

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Rachel Tham (R)

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.

Bircan Erbas (B)

School of Psychology and Public Health, La Trobe University, Victoria, Australia.

Shyamali C Dharmage (SC)

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia. Electronic address: s.dharmage@unimelb.edu.au.

Mimi Lk Tang (ML)

Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Australia.

Fahad Aldakheel (F)

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Caroline J Lodge (CJ)

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

Paul S Thomas (PS)

Department of Respiratory Medicine and Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, Australia.

Philip E Taylor (PE)

School of Life and Environmental Sciences, Deakin University, Geelong, Australia.

Michael J Abramson (MJ)

School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia.

Adrian J Lowe (AJ)

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie aigüe › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Microbiologie de l'environnement › Microbiologie de l'air › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Tests d'analyse de l'haleine › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Mécanique respiratoire › Expiration › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition par inhalation › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Stades d'organismes › Spores › Spores fongiques › Outdoor fungal spores and acute respiratory...
questionsmedicales.fr › Personnes › Disparités en matière de santé, minorités et populations vulnérables › Populations vulnérables › Outdoor fungal spores and acute respiratory...