Structure and Function of Multimeric G-Quadruplexes.
DNA:RNA hybrid
G-quadruplex
R-loop
dimer
multimer
oligomer
promoter
telomere
tetramer
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
24 Aug 2019
24 Aug 2019
Historique:
received:
13
08
2019
revised:
21
08
2019
accepted:
22
08
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
22
1
2020
Statut:
epublish
Résumé
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles. G-quadruplexes are often studied as monomers, but can also form a variety of higher-order structures. This increases the structural and functional diversity of G-quadruplexes, and recent evidence suggests that it could also be biologically important. In this review, we describe the types of multimeric topologies adopted by G-quadruplexes and highlight what is known about their sequence requirements. We also summarize the limited information available about potential biological roles of multimeric G-quadruplexes and suggest new approaches that could facilitate future studies of these structures.
Identifiants
pubmed: 31450559
pii: molecules24173074
doi: 10.3390/molecules24173074
pmc: PMC6749722
pii:
doi:
Substances chimiques
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund
ID : CZ.02.1.01/0.0/0.0/16_019/0000729
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