20S Proteasome as a Drug Target in Trichomonas vaginalis.

Amino Acid Sequence Animals Anti-Infective Agents / pharmacology Antitrichomonal Agents / pharmacology Cytoplasm / parasitology Drug Resistance / drug effects Female Humans Mice Mice, Inbred BALB C Parasitic Sensitivity Tests / methods Proteasome Endopeptidase Complex / drug effects Proteomics / methods Sexually Transmitted Diseases / drug therapy Trichomonas Infections / drug therapy Trichomonas Vaginitis / drug therapy Trichomonas vaginalis / drug effects
Trichomonas vaginalis proteasome protozoa

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
11 2019
Historique:
received: 01 03 2019
accepted: 19 08 2019
pubmed: 28 8 2019
medline: 7 8 2020
entrez: 28 8 2019
Statut: epublish

Résumé

Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent,

Identifiants

DOI: 10.1128/AAC.00448-19 PMID: 31451503 PMC: PMC6811414
pubmed: 31451503
pii: AAC.00448-19
doi: 10.1128/AAC.00448-19
pmc: PMC6811414
pii:
doi:

Substances chimiques

Anti-Infective Agents 0
Antitrichomonal Agents 0
Proteasome Endopeptidase Complex EC 3.4.25.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01 CA100851
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI146387
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI133393
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114671
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Anthony J O'Donoghue (AJ)

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA ajodonoghue@ucsd.edu leckmann@ucsd.edu.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
ORCID: 0000-0001-5695-0409

Betsaida Bibo-Verdugo (B)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

Yukiko Miyamoto (Y)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Steven C Wang (SC)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.

Justin Z Yang (JZ)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Douglas E Zuill (DE)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Shoun Matsuka (S)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.

Zhenze Jiang (Z)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.

Jehad Almaliti (J)

Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.

Conor R Caffrey (CR)

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.

William H Gerwick (WH)

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA.

Lars Eckmann (L)

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA ajodonoghue@ucsd.edu leckmann@ucsd.edu.
Department of Medicine, University of California, San Diego, La Jolla, California, USA.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Eucaryotes › Animaux › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antitrichomonas › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité parasitaire › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Proteasome endopeptidase complex › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies transmissibles › Maladies sexuellement transmissibles › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Infection › Maladies parasitaires › Protozooses › Trichomonase › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Maladies de l'appareil génital féminin › Maladies du vagin › Vaginite › Vaginite à Trichomonas › 20S Proteasome as a Drug Target in Trichomonas...
questionsmedicales.fr › Eucaryotes › Parabasalidea › Trichomonadida › Trichomonas › Trichomonas vaginalis › 20S Proteasome as a Drug Target in Trichomonas...