A theory of centriole duplication based on self-organized spatial pattern formation.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
04 11 2019
04 11 2019
Historique:
received:
25
04
2019
revised:
22
06
2019
accepted:
06
08
2019
pubmed:
28
8
2019
medline:
14
5
2020
entrez:
28
8
2019
Statut:
ppublish
Résumé
In each cell cycle, centrioles are duplicated to produce a single copy of each preexisting centriole. At the onset of centriole duplication, the master regulator Polo-like kinase 4 (Plk4) undergoes a dynamic change in its spatial pattern around the preexisting centriole, forming a single duplication site. However, the significance and mechanisms of this pattern transition remain unknown. Using super-resolution imaging, we found that centriolar Plk4 exhibits periodic discrete patterns resembling pearl necklaces, frequently with single prominent foci. Mathematical modeling and simulations incorporating the self-organization properties of Plk4 successfully generated the experimentally observed patterns. We therefore propose that the self-patterning of Plk4 is crucial for the regulation of centriole duplication. These results, defining the mechanisms of self-organized regulation, provide a fundamental principle for understanding centriole duplication.
Identifiants
pubmed: 31451615
pii: jcb.201904156
doi: 10.1083/jcb.201904156
pmc: PMC6829667
doi:
Substances chimiques
PLK4 protein, human
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3537-3547Informations de copyright
© 2019 Takao et al.
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