Adipocyte metabolism is improved by TNF receptor-targeting small RNAs identified from dried nuts.
3T3-L1 Cells
Adipocytes
/ drug effects
Adipose Tissue
/ pathology
Animals
Cytokines
/ metabolism
Desiccation
Female
Gene Expression Regulation, Plant
/ drug effects
Glucose
/ metabolism
HEK293 Cells
Humans
Hypertrophy
Inflammation
/ genetics
Insulin
/ pharmacology
Mice
Mice, Inbred C57BL
MicroRNAs
/ genetics
Nanoparticles
/ chemistry
Nuts
/ genetics
RAW 264.7 Cells
RNA, Messenger
/ genetics
RNA, Plant
/ genetics
Receptors, Tumor Necrosis Factor
/ metabolism
Disease model
Metabolism
Molecular medicine
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
03
2019
accepted:
30
07
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
28
8
2019
Statut:
epublish
Résumé
There is a growing interest in therapeutically targeting the inflammatory response that underlies age-related chronic diseases including obesity and type 2 diabetes. Through integrative small RNA sequencing, we show the presence of conserved plant miR159a and miR156c in dried nuts having high complementarity with the mammalian TNF receptor superfamily member 1a (Tnfrsf1a) transcript. We detected both miR159a and miR156c in exosome-like nut nanovesicles (NVs) and demonstrated that such NVs reduce Tnfrsf1a protein and dampen TNF-α signaling pathway in adipocytes. Synthetic single-stranded microRNAs (ss-miRs) modified with 2'-
Identifiants
pubmed: 31453381
doi: 10.1038/s42003-019-0563-7
pii: 563
pmc: PMC6704100
doi:
Substances chimiques
Cytokines
0
Insulin
0
MicroRNAs
0
RNA, Messenger
0
RNA, Plant
0
Receptors, Tumor Necrosis Factor
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
317Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests
Références
Cell. 2012 Aug 31;150(5):883-94
pubmed: 22939618
Appl Plant Sci. 2013 Dec 09;1(12):
pubmed: 25202509
Bioinformatics. 2014 Oct;30(19):2837-9
pubmed: 24930140
PeerJ. 2018 Jul 31;6:e5186
pubmed: 30083436
Nat Med. 2009 Sep;15(9):1082-7
pubmed: 19718037
Nat Rev Rheumatol. 2017 Nov 21;13(12):707-718
pubmed: 29158574
Nat Commun. 2016 Apr 27;7:11420
pubmed: 27117818
Science. 2011 Jul 8;333(6039):233-8
pubmed: 21680814
Adv Exp Med Biol. 2017;960:221-245
pubmed: 28585201
Public Health Nutr. 2007 Oct;10(10A):1164-72
pubmed: 17903326
RNA Biol. 2018;15(10):1273-1285
pubmed: 30306823
Nature. 2017 Feb 23;542(7642):450-455
pubmed: 28199304
Oxid Med Cell Longev. 2017;2017:9308310
pubmed: 29138682
Cell Death Differ. 2014 Jan;21(1):113-23
pubmed: 24096872
Plant Cell. 2008 Dec;20(12):3186-90
pubmed: 19074682
Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
pubmed: 24275495
Science. 2005 Feb 11;307(5711):932-5
pubmed: 15705854
Sci Rep. 2016 May 11;6:25761
pubmed: 27167363
Front Immunol. 2016 Jan 05;6:637
pubmed: 26779183
Oncologist. 2006 Apr;11(4):397-408
pubmed: 16614236
Front Pharmacol. 2017 Jul 12;8:460
pubmed: 28785220
Front Endocrinol (Lausanne). 2013 Jun 12;4:71
pubmed: 23781214
Cell Death Dis. 2013 Oct 17;4:e861
pubmed: 24136225
World J Gastroenterol. 2016 Nov 14;22(42):9300-9313
pubmed: 27895418
FEBS Lett. 2000 Mar 3;469(1):77-82
pubmed: 10708760
J Nutr Biochem. 2018 Jul;57:197-205
pubmed: 29751293
Genes Dev. 2014 Jan 1;28(1):44-57
pubmed: 24395246
Diabetes. 1998 Apr;47(4):515-22
pubmed: 9568681
PLoS One. 2017 Feb 27;12(2):e0172981
pubmed: 28241034
Curr Neurol Neurosci Rep. 2017 Apr;17(4):36
pubmed: 28337644
Cell Res. 2016 Feb;26(2):217-28
pubmed: 26794868
Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1360-8
pubmed: 22538807
Diabetes. 2002 Jun;51(6):1876-83
pubmed: 12031976
Cell Metab. 2014 Sep 2;20(3):433-47
pubmed: 25043816
Mediators Inflamm. 2014;2014:917698
pubmed: 24817795
Nucleic Acids Res. 2017 Jul 3;45(W1):W435-W439
pubmed: 28472523
Endocrinology. 2009 Sep;150(9):4124-34
pubmed: 19477937
Cytokine Growth Factor Rev. 2003 Oct;14(5):447-55
pubmed: 12948526
Mol Ther. 2016 Feb;24(1):96-105
pubmed: 26444082
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1695-704
pubmed: 22685206
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Diabetes. 2002 Nov;51(11):3176-88
pubmed: 12401708
Science. 1993 Jan 1;259(5091):87-91
pubmed: 7678183
Life Sci. 2017 Feb 1;170:56-63
pubmed: 27919820
J Biol Chem. 1996 May 31;271(22):13018-22
pubmed: 8662983
Mol Ther. 2016 May;24(5):946-55
pubmed: 26903376
Oncotarget. 2017 Aug 4;8(48):83407-83418
pubmed: 29137352
Perspect Clin Res. 2016 Apr-Jun;7(2):68-74
pubmed: 27141472
J Lipid Res. 2007 Apr;48(4):751-62
pubmed: 17202130
Plant J. 2016 Sep;87(5):507-32
pubmed: 27145194
Nucleic Acids Res. 2013 Jan;41(Database issue):D226-32
pubmed: 23125362
J Extracell Vesicles. 2014 Nov 24;3:25361
pubmed: 25425324
Adv Exp Med Biol. 2017;960:327-343
pubmed: 28585206
Nat Commun. 2013;4:1867
pubmed: 23695661
Arch Physiol Biochem. 2008 Jul;114(3):183-94
pubmed: 18629684
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Front Cell Neurosci. 2018 Jan 17;12:4
pubmed: 29387000
J Biol Chem. 1997 Jan 10;272(2):971-6
pubmed: 8995390
F1000Res. 2014 Jul 01;3:145
pubmed: 25383185
Mol Ther. 2014 Mar;22(3):522-534
pubmed: 23939022
RNA. 2012 Oct;18(10):1796-804
pubmed: 22912485