Dorsal hippocampus not always necessary in a radial arm maze delayed win-shift task.
declarative memory
hippocampus
inactivation
radial arm maze
working memory
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
24
10
2018
revised:
06
05
2019
accepted:
12
06
2019
pubmed:
28
8
2019
medline:
9
6
2021
entrez:
28
8
2019
Statut:
ppublish
Résumé
Spatial working memory is important for foraging and navigating the environment. However, its neural underpinnings remain poorly understood. The hippocampus, known for its spatial coding and involvement in spatial memory, is widely understood to be necessary for spatial working memory when retention intervals increase beyond seconds into minutes. Here, we describe new evidence that the dorsal hippocampus is not always necessary for spatial working memory for retention intervals of 8 min. Rats were trained to perform a delayed spatial win shift radial arm maze task with an 8-min delay between study and test phases. We then tested whether bilateral inactivation of the dorsal hippocampus between the study and test phases impaired behavioral performance at test. Inactivation was achieved through a bilateral infusion of lidocaine. Performance following lidocaine was compared to control trials, in which, sterile phosphate buffered saline (PBS) was infused. Test performance did not differ between the lidocaine and PBS conditions, remaining high in each. To explore the possibility that this insensitivity to inactivation was a result of overtraining, a second cohort of animals received substantially less training prior to the infusions. In this second cohort, lidocaine infusions did significantly impair task performance. These data indicate that successful performance of a spatial win-shift task on the 8-arm maze need not always be hippocampally dependent.
Substances chimiques
Anesthetics, Local
0
Lidocaine
98PI200987
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
121-129Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Babb, S. J., & Crystal, J. D. (2003). Spatial navigation on the radial maze with trial-unique intramaze cues and restricted extramaze cues. Behavioural Processes, 64(1), 103-111.
Brown, M. F., Rish, P. A., VonCulin, J. E., & Edberg, J. A. (1993). Spatial guidance of choice behavior in the radial-arm maze Journal of Experimental Psychology: Animal Behavior Processes, 19, 3.
Brown, M. F., & Bing, M. N. (1997). In the dark: Spatial choice when access to spatial cues is restricted. Animal Learning & Behavior, 25, 21-30.
Brown, M. F., & Moore, J. A. (1997). In the dark II: Spatial choice when access to extrinsic spatial cues is eliminated. Animal Learning & Behavior, 25, 335-346.
Buzsáki, G., & Moser, E. I. (2013). Memory, navigation and theta rhythm in the hippocampal-entorhinal system. Nature Neuroscience, 16(2), 130-138.
Chang, S. D., & Liang, K. C. (2017). The hippocampus integrates context and shock into a configural memory in contextual fear conditioning. Hippocampus, 27(2), 145-155.
Churchwell, J. C., & Kesner, R. P. (2011). Hippocampal-prefrontal dynamics in spatial working memory: Interactions and independent parallel processing. Behavioural Brain Research, 225(2), 389-395.
Crystal, J. D., Ketzenberger, J. A., & Alford, W. T. (2013). Practicing memory retrieval improves long-term retention in rats. Current Biology, 23(17), 708-709.
Floresco, S. B., Seamans, J. K., & Phillips, A. G. (1997). Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 17(5), 1880-1890.
Hartley, T., Lever, C., Burgess, N., & O'Keefe, J. (2014). Space in the brain: How the hippocampal formation supports spatial cognition. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 369, 1635.
Lehmann, H., Sparks, F. T., Spanswick, S. C., Hadikin, C., McDonald, R. J., & Sutherland, R. J. (2009). Making context memories independent of the hippocampus. Learning & Memory, 16(7), 417-420.
Lee, I., & Kesner, R. P. (2003a). Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23(4), 1517-1523.
Lee, I., & Kesner, R. P. (2003b). Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay. Behavioral Neuroscience, 117(5), 1044-1053.
Lopez, J., Herbeaux, K., Cosquer, B., Engeln, M., Muller, C., Lazarus, C., … de Vasconcelos, A. P. (2012). Context-dependent modulation of hippocampal and cortical recruitment during remote spatial memory retrieval. Hippocampus, 22(4), 827-841.
Maguire, E. A., Nannery, R., & Spiers, H. J. (2006). Navigation around London by a taxi driver with bilateral hippocampal lesions. Brain, 129(11), 2894-2907.
Malpeli, J. G. (1999). Reversible inactivation of subcortical sites by drug injection. Journal of Neuroscience Methods, 86(2), 119-128.
Martin, J. H. (1991). Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat. Neuroscience Letters, 127(2), 160-164 Bottom of Form.
McDaniel, W. F., Compton, D. M., & Smith, S. R. (1994). Spatial learning following posterior parietal or hippocampal lesions. Neuroreport, 5(14), 1713-1717.
O'Keefe, J., & Nadel, L. (1978). The hippocampus as a cognitive map. Oxford: Clarendon Press.
Olton, D. S., & Samuelson, R. J. (1976). Remembrance of places passed: Spatial memory in rats. Journal of Experimental Psychology: Animal Behavior Processes, 2, 97-116.
Olton, D. S., & Collison, C. (1979). Intramaze cues and “odor trails” fail to direct choice behavior on an elevated maze. Animal Learning & Behavior, 7, 221-223.
Packard, M. G., Regenold, W., Quirion, R., & White, N. M. (1990). Post-training injection of the acetylcholine M 2 receptor antagonist AF-DX 116 improves memory. Brain Research, 524(1), 72-76.
Paxinos, G., & Watson, C. (2007). The rat brain in stereotaxic coordinates. Amsterdam: Elsevier.
Potvin, O., Allen, K., Thibaudeau, G., Doré, F. Y., & Goulet, S. (2006). Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum. Behavioral Neuroscience, 120(2), 413-422.
Seamans, J. K., & Phillips, A. G. (1994). Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens in rats. Behavioral Neuroscience, 108, 456-468 Bottom of Form.
Seamans, J. K., Floresco, S. B., & Phillips, A. G. (1995). Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex. Behavioral Neuroscience, 109, 1063-1073.
Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., Wood, E. R., … Morris, R. G. M. (2007). Schemas and memory consolidation. Science, 315(5821), 76.
Welsh, J. P., & Harvey, J. A. (1991). Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus. Journal of Physiology (London), 444, 459-480.
Winocur, G., Moscovitch, M., Fogel, S., Rosenbaum, R. S., & Sekeres, M. (2005). Preserved spatial memory after hippocampal lesions: Effects of extensive experience in a complex environment. Nature Neuroscience, 8(3), 273-275.
Yoon, T., Okada, J., Jung, M. W., & Kim, J. J. (2008). Prefrontal cortex and hippocampus subserve different components of working memory in rats. Learning & Memory, 15(3), 97-105.