Dual inhibition of cannabinoid CB
Animals
Cannabinoid Receptor Antagonists
/ pharmacology
Cell Line, Transformed
Diet, High-Fat
/ adverse effects
Humans
Male
Mice
Mice, Inbred C57BL
Nitric Oxide Synthase Type II
/ antagonists & inhibitors
Obesity
/ etiology
Receptor, Cannabinoid, CB1
/ antagonists & inhibitors
Renal Insufficiency, Chronic
/ etiology
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
09
2018
revised:
21
08
2019
accepted:
22
08
2019
pubmed:
28
8
2019
medline:
10
4
2021
entrez:
28
8
2019
Statut:
ppublish
Résumé
Obesity, an important risk factor for developing chronic kidney disease (CKD), affects the kidneys by two main molecular signalling pathways: the endocannabinoid/CB Here, we describe the effect of a novel peripherally restricted, orally bioavailable dual CB Enhanced expression of CB Collectively, our results highlight the therapeutic relevance of blocking CB
Sections du résumé
BACKGROUND AND PURPOSE
Obesity, an important risk factor for developing chronic kidney disease (CKD), affects the kidneys by two main molecular signalling pathways: the endocannabinoid/CB
EXPERIMENTAL APPROACH
Here, we describe the effect of a novel peripherally restricted, orally bioavailable dual CB
KEY RESULTS
Enhanced expression of CB
CONCLUSIONS AND IMPLICATIONS
Collectively, our results highlight the therapeutic relevance of blocking CB
Identifiants
pubmed: 31454063
doi: 10.1111/bph.14849
pmc: PMC6976880
doi:
Substances chimiques
Cannabinoid Receptor Antagonists
0
Receptor, Cannabinoid, CB1
0
Nitric Oxide Synthase Type II
EC 1.14.13.39
Nos2 protein, mouse
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-127Subventions
Organisme : European Research Council
ID : 676841
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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