PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons.
Animals
Corpus Callosum
/ cytology
Female
Intracellular Signaling Peptides and Proteins
/ genetics
Male
Membrane Glycoproteins
/ genetics
Mice
Mice, Inbred C57BL
Motor Cortex
/ cytology
Neuroanatomical Tract-Tracing Techniques
Neurons
/ cytology
Semaphorins
/ genetics
Somatosensory Cortex
/ cytology
Journal
Molecular and cellular neurosciences
ISSN: 1095-9327
Titre abrégé: Mol Cell Neurosci
Pays: United States
ID NLM: 9100095
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
15
04
2019
revised:
05
08
2019
accepted:
19
08
2019
pubmed:
28
8
2019
medline:
6
5
2020
entrez:
28
8
2019
Statut:
ppublish
Résumé
The corpus callosum is the largest bundle of commissural fibres that transfer information between the two cerebral hemispheres. Callosal projection neurons (CPNs) are a diverse population of pyramidal neurons within the neocortex that mainly interconnect homotopic regions of the opposite cortices. Nevertheless, some CPNs are involved in heterotopic projections between distinct cortical areas or to subcortical regions such as the striatum. In this study, we showed that the axon guidance receptor PlexinD1 is expressed by a large proportion of heterotopically projecting CPNs in layer 5A of the primary somatosensory (S1) and motor (M1) areas. Retrograde tracing of M1 CPNs projecting to the contralateral striatum revealed the presence of ectopic neurons aberrantly located in layers 2/3 of Plxnd1 and Sema3e mutant cortices. These results showed that Sema3E/PlexinD1 signalling controls the laminar distribution of heterotopically projecting CPNs.
Identifiants
pubmed: 31454665
pii: S1044-7431(19)30114-9
doi: 10.1016/j.mcn.2019.103397
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Membrane Glycoproteins
0
Plxnd1 protein, mouse
0
Sema3e protein, mouse
0
Semaphorins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103397Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.