FSH-metabolic circuitry and menopause.
FSH
bone
menopause
obesity
osteoporosis
Journal
Journal of molecular endocrinology
ISSN: 1479-6813
Titre abrégé: J Mol Endocrinol
Pays: England
ID NLM: 8902617
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
18
08
2019
accepted:
27
08
2019
pubmed:
28
8
2019
medline:
17
6
2020
entrez:
28
8
2019
Statut:
ppublish
Résumé
FSH has a primary function in procreation, wherein it induces estrogen production in females and regulates spermatogenesis in males. However, in line with our discoveries over the past decade of non-unitary functions of pituitary hormones, we and others have described hitherto uncharacterized functions of FSH. Through high-affinity receptors, some of which are variants of the ovarian FSH receptor (FSHR), FSH regulates bone mass, adipose tissue function, energy metabolism, and cholesterol production in both sexes. These newly described actions of FSH may indeed be relevant to the pathogenesis of bone loss, dysregulated energy homeostasis, and disordered lipid metabolism that accompany the menopause in females and aging in both genders. We are therefore excited about the possibility of modulating circulating FSH levels toward a therapeutic benefit for a host of age-associated diseases, including osteoporosis, obesity and dyslipidemia, among other future possibilities.
Identifiants
pubmed: 31454787
doi: 10.1530/JME-19-0152
pii: JME-19-0152.R1
pmc: PMC6992500
mid: NIHMS1539524
doi:
pii:
Substances chimiques
Antibodies, Blocking
0
Follicle Stimulating Hormone
9002-68-0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
R73-R80Subventions
Organisme : NIA NIH HHS
ID : R01 AG040132
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR067066
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113627
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG060917
Pays : United States
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