SILAC-Based Quantification of TGFBR2-Regulated Protein Expression in Extracellular Vesicles of Microsatellite Unstable Colorectal Cancers.

Amino Acids / metabolism Biological Assay / methods Cell Line, Tumor Colorectal Neoplasms / genetics Extracellular Vesicles / metabolism Gene Expression Regulation, Neoplastic Humans Isotope Labeling Microsatellite Instability Protein Biosynthesis Protein Interaction Mapping Protein Interaction Maps Receptor, Transforming Growth Factor-beta Type II / metabolism Reproducibility of Results
DNA mismatch repair TGFBR2 colorectal cancer exosomes extracellular vesicles microsatellite instability proteomics stable isotope labeling with amino acids in cell culture (SILAC)

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Aug 2019
Historique:
received: 17 07 2019
revised: 21 08 2019
accepted: 23 08 2019
entrez: 29 8 2019
pubmed: 29 8 2019
medline: 23 1 2020
Statut: epublish

Résumé

Microsatellite unstable (MSI) colorectal cancers (CRCs) are characterized by mutational inactivation of

Identifiants

DOI: 10.3390/ijms20174162 PMID: 31454892 PMC: PMC6747473
pubmed: 31454892
pii: ijms20174162
doi: 10.3390/ijms20174162
pmc: PMC6747473
pii:
doi:

Substances chimiques

Amino Acids 0
Receptor, Transforming Growth Factor-beta Type II EC 2.7.11.30
TGFBR2 protein, human EC 2.7.11.30

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Fabia Fricke (F)

Department Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
ORCID: 0000-0001-5629-4368

Malwina Michalak (M)

Department Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

Uwe Warnken (U)

Functional Proteome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Ingrid Hausser (I)

EM-Lab, Institute of Pathology, Im Neuenheimer Feld 224, Heidelberg University Hospital, 69120 Heidelberg, Germany.
ORCID: 0000-0002-1095-4962

Martina Schnölzer (M)

Functional Proteome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Jürgen Kopitz (J)

Department Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

Johannes Gebert (J)

Department Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany. johannes.gebert@med.uni-heidelberg.de.
Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany. johannes.gebert@med.uni-heidelberg.de.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Techniques d'investigation › Dosage biologique › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des microsatellites › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Cartographie d'interactions entre protéines › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Cartes d'interactions protéiques › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs TGF-bêta › Récepteur de type II du facteur de croissance transformant bêta › SILAC-Based Quantification of TGFBR2-Regulated...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › SILAC-Based Quantification of TGFBR2-Regulated...