Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice.
Asthma
Children
Kynurenine
Neopterin
Tryptophan
Journal
Italian journal of pediatrics
ISSN: 1824-7288
Titre abrégé: Ital J Pediatr
Pays: England
ID NLM: 101510759
Informations de publication
Date de publication:
28 Aug 2019
28 Aug 2019
Historique:
received:
28
03
2019
accepted:
06
08
2019
entrez:
29
8
2019
pubmed:
29
8
2019
medline:
12
2
2020
Statut:
epublish
Résumé
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.
Identifiants
pubmed: 31455379
doi: 10.1186/s13052-019-0699-6
pii: 10.1186/s13052-019-0699-6
pmc: PMC6712831
doi:
Substances chimiques
Neopterin
670-65-5
Tryptophan
8DUH1N11BX
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
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