Comparative Genomics of Antibiotic-Resistant Uropathogens Implicates Three Routes for Recurrence of Urinary Tract Infections.


Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
27 08 2019
Historique:
entrez: 29 8 2019
pubmed: 29 8 2019
medline: 28 4 2020
Statut: epublish

Résumé

The rise of antimicrobial resistance in uropathogens has complicated the management of urinary tract infections (UTIs), particularly in patients who are afflicted by recurrent episodes of UTIs. Antimicrobial-resistant (AR) uropathogens persistently colonizing individuals at asymptomatic time points have been implicated in the pathophysiology of UTIs. The dynamics of uropathogen persistence following the resolution of symptomatic disease are, however, mostly unclear. To further our understanding, we determined longitudinal AR uropathogen carriage and clonal persistence of uropathogenic

Identifiants

pubmed: 31455657
pii: mBio.01977-19
doi: 10.1128/mBio.01977-19
pmc: PMC6712402
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI137321
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002346
Pays : United States
Organisme : NCEZID CDC HHS
ID : U54 CK000609
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States

Informations de copyright

Copyright © 2019 Thänert et al.

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Auteurs

Robert Thänert (R)

The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Kimberly A Reske (KA)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

Tiffany Hink (T)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

Meghan A Wallace (MA)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

Bin Wang (B)

The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Drew J Schwartz (DJ)

The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

Sondra Seiler (S)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

Candice Cass (C)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

C A Burnham (CA)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.

Erik R Dubberke (ER)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA edubberk@wustl.edu j.kwon@wustl.edu dantas@wustl.edu.

Jennie H Kwon (JH)

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA edubberk@wustl.edu j.kwon@wustl.edu dantas@wustl.edu.

Gautam Dantas (G)

The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA edubberk@wustl.edu j.kwon@wustl.edu dantas@wustl.edu.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Biomedical Engineering, Washington University, St. Louis, Missouri, USA.

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