A promising bioconjugate vaccine against hypervirulent
Animals
Bacterial Vaccines
/ administration & dosage
Carrier Proteins
/ genetics
Community-Acquired Infections
/ immunology
Disease Models, Animal
Drug Resistance, Multiple, Bacterial
Escherichia coli
/ genetics
Female
Humans
Immunogenicity, Vaccine
Klebsiella Infections
/ microbiology
Klebsiella pneumoniae
/ immunology
Lipopolysaccharides
/ genetics
Metabolic Engineering
Mice
Vaccines, Conjugate
/ administration & dosage
Virulence
/ immunology
Virulence Factors
/ genetics
bioconjugation
glycoconjugate
hypervirulent Klebsiella pneumoniae
vaccine
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
pubmed:
29
8
2019
medline:
9
4
2020
entrez:
29
8
2019
Statut:
ppublish
Résumé
Hypervirulent
Identifiants
pubmed: 31455739
pii: 1907833116
doi: 10.1073/pnas.1907833116
pmc: PMC6744904
doi:
Substances chimiques
Bacterial Vaccines
0
Carrier Proteins
0
Lipopolysaccharides
0
Vaccines, Conjugate
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18655-18663Subventions
Organisme : NIAID NIH HHS
ID : K08 AI127714
Pays : United States
Organisme : NIAID NIH HHS
ID : R41 AI136233
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Conflict of interest statement: M.F.F. and C.M.H. have a financial stake in VaxNewMo, a for-profit entity developing bioconjugate vaccines against Streptococcus pneumoniae and Klebsiella pneumoniae using patented technology derived from the data presented in this and other published manuscripts.
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