Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants.
Adult
Bipolar Disorder
/ physiopathology
Case-Control Studies
Cohort Studies
Female
Healthy Volunteers
/ psychology
Humans
Intelligence
/ physiology
Intelligence Tests
Linear Models
Norway
Obstetric Labor Complications
/ psychology
Pregnancy
Schizophrenia
/ diagnosis
Schizophrenic Psychology
Young Adult
Bipolar spectrum
cognition
intelligence
mood disorders bipolar
neuropsychology
obstetric complications
obstetric gynecology
premorbid IQ
schizophrenia
schizophrenia spectrum
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
29
8
2019
medline:
16
6
2021
entrez:
29
8
2019
Statut:
ppublish
Résumé
Whether severe obstetric complications (OCs), which harm neural function in offspring, contribute to impaired cognition found in psychiatric disorders is currently unknown. Here, we sought to evaluate how a history of severe OCs is associated with cognitive functioning, indicated by Intelligence Quotient (IQ). We evaluated the associations of a history of OCs and IQ in 622 healthy controls (HC) and 870 patients on the schizophrenia (SCZ) - bipolar disorder (BIP) spectrum from the ongoing Thematically Organized Psychosis study cohort, Oslo, Norway. Participants underwent assessments using the NART (premorbid IQ) and the WASI (current IQ). Information about OCs was obtained from the Medical Birth Registry of Norway. Multiple linear regression models were used for analysis. Severe OCs were equally common across groups. SCZ patients with OCs had lower performances on both premorbid and current IQ measures, compared to those without OCs. However, having experienced more than one co-occurring severe OC was associated with lower current IQ in all groups. Severe OCs were associated with lower IQ in the SCZ group and in the BIP and HC groups, but only if they had experienced more than one severe OC. Low IQ might be a neurodevelopmental marker for SCZ; wherein, severe OCs influence cognitive abilities and increase the risk of developing SCZ. Considering OCs as a variable of neurodevelopmental risk for severe mental illness may promote the development of neuroprotective interventions, improve outcome in vulnerable newborns and advance our ability to make clinical prognoses.
Sections du résumé
BACKGROUND
Whether severe obstetric complications (OCs), which harm neural function in offspring, contribute to impaired cognition found in psychiatric disorders is currently unknown. Here, we sought to evaluate how a history of severe OCs is associated with cognitive functioning, indicated by Intelligence Quotient (IQ).
METHODS
We evaluated the associations of a history of OCs and IQ in 622 healthy controls (HC) and 870 patients on the schizophrenia (SCZ) - bipolar disorder (BIP) spectrum from the ongoing Thematically Organized Psychosis study cohort, Oslo, Norway. Participants underwent assessments using the NART (premorbid IQ) and the WASI (current IQ). Information about OCs was obtained from the Medical Birth Registry of Norway. Multiple linear regression models were used for analysis.
RESULTS
Severe OCs were equally common across groups. SCZ patients with OCs had lower performances on both premorbid and current IQ measures, compared to those without OCs. However, having experienced more than one co-occurring severe OC was associated with lower current IQ in all groups.
CONCLUSIONS
Severe OCs were associated with lower IQ in the SCZ group and in the BIP and HC groups, but only if they had experienced more than one severe OC. Low IQ might be a neurodevelopmental marker for SCZ; wherein, severe OCs influence cognitive abilities and increase the risk of developing SCZ. Considering OCs as a variable of neurodevelopmental risk for severe mental illness may promote the development of neuroprotective interventions, improve outcome in vulnerable newborns and advance our ability to make clinical prognoses.
Identifiants
pubmed: 31456537
doi: 10.1017/S0033291719002046
pii: S0033291719002046
pmc: PMC7477368
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1914-1922Références
Br J Psychiatry. 2006 Jul;189:3-11
pubmed: 16816299
J Psychiatr Res. 2009 Dec;43(16):1287-93
pubmed: 19473666
NPJ Schizophr. 2015 Nov 04;1:15043
pubmed: 27336046
Am J Epidemiol. 1978 Nov;108(5):341-6
pubmed: 727202
Psychiatry Res. 2019 Jan;271:23-30
pubmed: 30458317
Mol Psychiatry. 2008 Sep;13(9):873-7
pubmed: 18195713
Arch Gen Psychiatry. 2012 Jun;69(6):E1-8
pubmed: 22660967
Am J Psychiatry. 2008 May;165(5):579-87
pubmed: 18413704
Am J Psychiatry. 1993 Sep;150(9):1355-62
pubmed: 8352346
Arch Gen Psychiatry. 2002 May;59(5):449-56
pubmed: 11982449
Psychol Med. 2014 Apr;44(5):975-85
pubmed: 23803260
Am J Psychiatry. 2002 Jul;159(7):1080-92
pubmed: 12091183
Behav Genet. 2001 Mar;31(2):209-17
pubmed: 11545537
Schizophr Bull. 2015 Jul;41(4):892-9
pubmed: 25528757
Mol Psychiatry. 2020 Apr;25(4):844-853
pubmed: 30610197
Schizophr Res. 2000 Feb 14;41(3):417-29
pubmed: 10728719
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Science. 2007 Oct 26;318(5850):576-7
pubmed: 17962542
JAMA. 1994 Dec 14;272(22):1749-56
pubmed: 7966923
Br J Psychiatry. 1995 Dec;167(6):786-93
pubmed: 8829748
Am J Psychiatry. 2013 Nov;170(11):1275-84
pubmed: 23771174
Schizophr Res. 2011 Nov;132(2-3):220-7
pubmed: 21764562
Schizophr Bull. 2017 Oct 21;43(6):1190-1196
pubmed: 28981842
Front Psychiatry. 2014 May 07;5:45
pubmed: 24847284
Psychol Med. 2001 Apr;31(3):451-8
pubmed: 11305853
Schizophr Bull. 2018 Jun 6;44(4):854-864
pubmed: 29136250
J Psychiatr Res. 1994 Nov-Dec;28(6):519-30
pubmed: 7699611
Schizophr Bull. 2014 Mar;40 Suppl 2:S131-7
pubmed: 24562492
Schizophr Bull. 2012 Mar;38(2):209-14
pubmed: 21857009
Schizophr Bull. 2015 Sep;41(5):1095-104
pubmed: 25616505
Psychol Med. 2017 Jul;47(10):1848-1864
pubmed: 28241891
Nat Rev Neurosci. 2017 Dec;18(12):727-740
pubmed: 29070826
J Affect Disord. 2016 Mar 1;192:109-15
pubmed: 26720009
World Psychiatry. 2018 Feb;17(1):49-66
pubmed: 29352556
Schizophr Bull. 2015 Nov;41(6):1349-59
pubmed: 25904725
Compr Psychiatry. 2007 Jan-Feb;48(1):88-94
pubmed: 17145287
Nat Med. 2018 Jun;24(6):792-801
pubmed: 29808008