Specific Interactions between Rifamycin Antibiotics and Water Influencing Ability To Overcome Natural Cell Barriers and the Range of Antibacterial Potency.
Anti-Bacterial Agents
/ chemistry
Biological Transport
/ drug effects
Cell Membrane
/ drug effects
DNA-Directed RNA Polymerases
Gram-Negative Bacteria
/ drug effects
Hydrophobic and Hydrophilic Interactions
Models, Chemical
Molecular Conformation
Permeability
Rifampin
/ analogs & derivatives
Rifamycins
/ chemistry
Structure-Activity Relationship
Water
/ chemistry
RNA polymerases
ansamycins conformation
chameleonic macrocyclic drugs
hydrates
membrane permeability
zwitterions
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
11 10 2019
11 10 2019
Historique:
pubmed:
29
8
2019
medline:
7
7
2020
entrez:
29
8
2019
Statut:
ppublish
Résumé
Rifamycins are a group of macrocyclic antibiotics mainly used for the treatment of various bacterial infections including tuberculosis. Spectroscopic studies of rifamycins evidence the formation of temperature- and solvent-dependent equilibria between A-, B-, and C-type conformers in solutions. The B- and C-type conformers of rifamycin antibiotics are exclusively formed in the presence of water molecules. A- and B-type conformers exhibit a hydrophilic and "open"
Identifiants
pubmed: 31461259
doi: 10.1021/acsinfecdis.9b00176
doi:
Substances chimiques
Anti-Bacterial Agents
0
Rifamycins
0
Water
059QF0KO0R
DNA-Directed RNA Polymerases
EC 2.7.7.6
Rifampin
VJT6J7R4TR
rifapentine
XJM390A33U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM