Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Animals
Astrocytes
/ drug effects
Autophagy
/ drug effects
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cells, Cultured
Disease Models, Animal
ErbB Receptors
/ antagonists & inhibitors
Eye
/ metabolism
Gefitinib
/ pharmacology
Lysosomes
/ drug effects
Mechanistic Target of Rapamycin Complex 1
/ antagonists & inhibitors
Microscopy, Immunoelectron
Morpholines
/ pharmacology
Persistent Hyperplastic Primary Vitreous
/ genetics
Rats
Signal Transduction
/ genetics
Sirolimus
/ pharmacology
beta-Crystallin A Chain
/ genetics
Astrocytes
CRYBA1 (ßA3/A1-crystallin)
EGFR (epidermal growth factor receptor)
MTORC1 (mechanistic target of rapamycin complex 1)
Nuc1 rat
autophagy
gefitinib
hyaloid vessels
lysosomes
persistent fetal vasculature (PFV) disease
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
30
8
2019
medline:
13
5
2021
entrez:
30
8
2019
Statut:
ppublish
Résumé
Persistent fetal vasculature (PFV) is a human disease that results from failure of the fetal vasculature to regress normally. The regulatory mechanisms responsible for fetal vascular regression remain obscure, as does the underlying cause of regression failure. However, there are a few animal models that mimic the clinical manifestations of human PFV, which can be used to study different aspects of the disease. One such model is the Nuc1 rat model that arose from a spontaneous mutation in the ACTB: actin, beta; CCND3: cyclin 3; CDK6: cyclin-dependent kinase 6; CHQ: chloroquine; COL4A1: collagen, type IV, alpha 1; CRYBA1: crystallin, beta A1; DAPI: 4'6-diamino-2-phenylindole; EGFR: epidermal growth factor receptor; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFAP: glial fibrillary growth factor; KDR: kinase insert domain protein receptor; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MKI67: antigen identified by monoclonal antibody Ki 67; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP: poly (ADP-ribose) polymerase family; PCNA: proliferating cell nuclear antigen; PFV: persistent fetal vasculature; PHPV: persistent hyperplastic primary vitreous; RPE: retinal pigmented epithelium; RPS6: ribosomal protein S6; RPS6KB1: ribosomal protein S6 kinase, polypeptide 1; SQSTM1/p62: sequestome 1; TUBB: tubulin, beta; VCL: vinculin; VEGFA: vascular endothelial growth factor A; WT: wild type.
Identifiants
pubmed: 31462148
doi: 10.1080/15548627.2019.1660545
pmc: PMC7469569
doi:
Substances chimiques
Morpholines
0
beta-Crystallin A Chain
0
(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol
970JJ37FPW
ErbB Receptors
EC 2.7.10.1
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Gefitinib
S65743JHBS
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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