Prediction of the skin sensitization potential of didecyldimethylammonium chloride and 3,7-dimethyl-2,6-octadienal and mixtures of these compounds with the excipient ethylene glycol through the human Cell Line Activation Test and the Direct Peptide Reactivity Assay.
Acyclic Monoterpenes
/ administration & dosage
Animal Testing Alternatives
/ methods
B7-2 Antigen
/ metabolism
Biological Assay
/ methods
Cell Line
Ethylene Glycol
/ administration & dosage
Excipients
/ administration & dosage
Humans
Intercellular Adhesion Molecule-1
/ metabolism
Quaternary Ammonium Compounds
/ adverse effects
Skin
/ drug effects
Skin Irritancy Tests
/ methods
Human Cell Line Activation Test
citral
didecyldimethylammonium chloride
direct peptide reactivity test
ethylene glycol mixture
skin sensitization alternative method
Journal
Toxicology and industrial health
ISSN: 1477-0393
Titre abrégé: Toxicol Ind Health
Pays: England
ID NLM: 8602702
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
7
2
2020
Statut:
ppublish
Résumé
In commercial products such as household deodorants or biocides, didecyldimethylammonium chloride (DDAC) often serves as an antimicrobial agent, citral serves as a fragrance agent, and the excipient ethylene glycol (EG) is used to dissolve the active ingredients. The skin sensitization (SS) potentials of each of these substances are still being debated. Moreover, mixtures of DDAC or citral with EG have not been evaluated for SS potency. The
Identifiants
pubmed: 31462197
doi: 10.1177/0748233719869514
doi:
Substances chimiques
Acyclic Monoterpenes
0
B7-2 Antigen
0
Excipients
0
Quaternary Ammonium Compounds
0
Intercellular Adhesion Molecule-1
126547-89-5
Ethylene Glycol
FC72KVT52F
citral
T7EU0O9VPP
didecyldimethylammonium
Z7F472XQPA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM